| GeneLibs

题目:: [T-cadherin suppresses the cell proliferation of mouse melanoma B16F10 and tumor angiogenesis in the model of the chorioallantoic membrane].
作者:: Iurlova(E I),Rubina(K A),Sysoeva(V Iu),Sharonov(G V),Semina(E V),Parfenova(E V),Tkachuk(V A)
状态:: 发布时间2010-09-28 , 更新时间 2010-09-28
期刊:: Ontogenez
摘要:: The influence of T-cadherin on the pigmentation and proliferation of mouse melanoma B16F10 cells in vitro and on the growth and neovascularization of tumor cell masses formed by the B16F10 cells in a model of the chorioallantoic membrane of a chicken embryo is studied. It is found that the proliferative activity of the cells decreases in the cell culture of mouse melanoma upon the hyperexpression of T-cadherin in comparison with the cells in the control. It is shown in experiments in vitro that the B16F10 cells with the hyperexpression of T-cadherin are less adaptive to the chorioallantoic membrane than the control cells. In addition, it is found that the control cells of mouse melanoma form tumors with area more 0.1 mm2 more often than the cells with the hyperexpression of T-cadherin and the amount of the vessels growing to tumor cell masses formed by the cells with the hyperexpression of T-cadherin is significantly lower than the same index for the cells in the control. Thus, the hyperexpression of T-cadherin in the B16F10 cells suppresses the proliferation of these cells in vitro and the growth of the tumor masses formed by melanoma cells on the chorioallantoic membrane and their neovascularization in vivo are demonstrated.
语言:: rus
DOI:

文献库文献相关信息

DataTable pData

联系方式

微信公众号

文献库 文献相关信息

DataTable pData

联系方式

微信公众号

文献库文献相关信息