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题目:: α-Catenin inhibits glioma cell migration, invasion, and proliferation by suppression of β-catenin transactivation.
作者:: Ji(Haitao),Wang(Ji),Fang(Bingliang),Fang(Xuexun),Lu(Zhimin)
状态:: 发布时间2011-06-16 , 更新时间 2011-06-16
期刊:: J Neurooncol
摘要:: Patients with glioblastomas, the most common primary tumors of the central nervous system, have poor prognoses because of uncontrolled tumor cell invasion and proliferation. β-Catenin plays an important role in tumor development. However, whether α-catenin expression contributes to β-catenin transactivation in glioma cells is largely unknown. We report here that α-catenin expression abrogates epidermal growth factor receptor (EGFR)-activation-induced β-catenin nuclear translocation in human glioblastoma cells, thereby attenuating β-catenin transactivation and the expression of its downstream genes CCND1 and c-myc. In addition, ectopic expression of α-catenin or depletion of β-catenin suppresses EGF-promoted glioblastoma cell migration, invasion, and proliferation. In contrast, α-catenin depletion promotes β-catenin nuclear translocation and transactivation, and tumor cell motility and growth. These findings reveal the importance of β-catenin regulation by α-catenin in cellular activities of glioblastoma cells.
语言:: eng
DOI:: 10.1007/s11060-010-0413-4

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