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题目:: Cytotoxic effects of activated alveolar macrophages on lung carcinoma cells via cell-to-cell contact and nitric oxide.
作者:: Sawachi(Keiichi),Shimada(Yasuteru),Taniguchi(Hiroaki),Hirota(Keiji),Inagawa(Hiroyuki),Kohchi(Chie),Soma(Gen-Ichiro),Makino(Kimiko),Terada(Hiroshi)
状态:: 发布时间2010-09-27 , 更新时间 2013-11-21
期刊:: Anticancer Res
摘要:: It is possible that macrophages may be effective for cancer treatment because once activated, lung macrophages have enhanced contact with lung tumor cells and have a cytotoxic effect. In this paper, we report that nitric oxide (NO) produced by lung macrophages activated with lipopolysaccharide (LPS) suppressed cell growth of human lung adenocarcinoma cells.,A549, a lung adenocarcinoma cell line, was cultured with NR8383, a rat alveolar macrophage cell line, in the presence and absence of LPS. The effect of LPS on the growth rate of A549 cells was examined as a function of NO production under cell-to-cell contact conditions.,NR8383 cells showed potent cytostatic and cytocidal effects on A549 cells when both cells were co-cultured in the presence of LPS. These effects were mainly due to the production of NO, but another possible mechanism, such as cell-to-cell contact, may also be involved.,Activation of alveolar macrophages by LPS suppresses the growth of lung carcinoma cells via NO production under cell-to-cell contact conditions.
语言:: eng
DOI:

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