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PMID: 2085097 Published · ppublish English Case Reports Journal Article Review

Corticonigral degeneration with neuronal achromasia and basal neurofibrillary tangles.

Acta neuropathologica ·Vol. 81 ·No. 1 ·1990-00-00 ·Pages 89-94

Paulus W, Selim M

Abstract

A man, aged 58 years, suffered from progressive dementia, parkinsonism, and gaze paralysis for 30 months. Autopsy revealed severe degeneration of the substantia nigra, numerous swollen chromatolytic neurons within the cerebral cortex, scattered basal neurofibrillary tangles, and gliosis of the cerebral white matter and basal ganglia. Unusual globular inclusions positive for tau protein were detected within neurons of the upper cortical layers. Although the pathological findings were comparable with corticonigral degeneration with neuronal achromasia, several clinical and pathological features characteristic for progressive supranuclear palsy, progressive subcortical gliosis, and Pick's disease in this and the nine previously reported cases hampered the unequivocal nosological placement.

MeSH Terms
Basal Ganglia/pathology Brain Diseases/diagnosis,pathology Cerebral Cortex/pathology Humans Male Middle Aged Neurons/pathology Substantia Nigra/pathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Paulus W
Ludwig-Boltzmann-Institut für Klinische Neurobiologie, Wien, Austria.
Selim M
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Article Info
Journal
Acta neuropathologica
Abbr.
Acta Neuropathol
ISSN
0001-6322
DOI
10.1007/BF00662643
Published
1990-00-00
Pages
89-94
Language
English
Region
Germany
NLM ID
0412041
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00662643 View journal details
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