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PMID: 20847819 Published · ppublish English Journal Article

High-Mobility Group A (HMGA) Proteins and Breast Cancer.

Breast care (Basel, Switzerland) ·Vol. 5 ·No. 2 ·2010-00-00 ·Pages 81-85

Peluso S, Chiappetta G

Abstract

The high-mobility group A (HMGA) protein family includes HMGA1a, HMGA1b and HMGA1c, which are encoded by the same gene through alternative splicing, and the closely related HMGA2 protein. HMGA proteins have been found to be abundant in several malignant neoplasias, including colorectal, prostate, cervical, lung, thyroid and breast carcinoma. HMGA proteins can be ideal candidates for the identification of new prognosis and diagnosis factors with non-invasive methods. To provide some clarity regarding the abundance of articles on this topic, here we focus on the relationship between HMGA proteins and breast cancer and their clinical perspective in the development of new therapeutic strategies.

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Peluso Silvia
Istituto Nazionale dei Tumori, Fondazione Pascale, Naples, Italy.
Chiappetta Gennaro
References (36)
36 references, click to expand
  1. The HMGA proteins: a myriad of functions (Review).
    Int J Oncol. 2008 Feb;32(2):289-305 PMID: 18202751
  2. Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y).
    J Biol Chem. 1998 Apr 17;273(16):9755-60 PMID: 9545312
  3. Detection of HMGI-C in the peripheral blood of breast cancer patients.
    Eur J Cancer. 2000 Oct;36(15):1944-8 PMID: 11000575
  4. Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer.
    J Natl Cancer Inst. 1999 Jun 2;91(11):943-9 PMID: 10359546
  5. Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma.
    Mol Cell Biol. 2003 Apr;23(7):2225-38 PMID: 12640109
  6. BRCA2 hereditary breast cancer pathophenotype.
    Breast Cancer Res Treat. 1997 Jul;44(3):275-7 PMID: 9266108
  7. Regulation of BRCA1 and BRCA2 expression in human breast cancer cells by DNA-damaging agents.
    Oncogene. 1998 Apr 30;16(17):2229-41 PMID: 9619832
  8. HMGA1 protein expression in familial breast carcinoma patients.
    Eur J Cancer. 2010 Jan;46(2):332-9 PMID: 19896837
  9. Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene.
    Nucleic Acids Res. 1993 Sep 11;21(18):4259-67 PMID: 8414980
  10. Genetic analysis of breast cancer in the cancer and steroid hormone study.
    Am J Hum Genet. 1991 Feb;48(2):232-42 PMID: 1990835
  11. Inhibition of HMGI-C protein synthesis suppresses retrovirally induced neoplastic transformation of rat thyroid cells.
    Mol Cell Biol. 1995 Mar;15(3):1545-53 PMID: 7862147
  12. Revised nomenclature for high mobility group (HMG) chromosomal proteins.
    Trends Biochem Sci. 2001 Mar;26(3):152-3 PMID: 11246012
  13. Hereditary breast cancer: pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage.
    Cancer. 1996 Feb 15;77(4):697-709 PMID: 8616762
  14. Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor.
    J Biol Chem. 1999 Aug 6;274(32):22563-8 PMID: 10428834
  15. Extracellular plasma RNA from colon cancer patients is confined in a vesicle-like structure and is mRNA-enriched.
    RNA. 2008 Jul;14(7):1424-32 PMID: 18456845
  16. HMGA1 protein overexpression in human breast carcinomas: correlation with ErbB2 expression.
    Clin Cancer Res. 2004 Nov 15;10(22):7637-44 PMID: 15569996
  17. High level expression of the HMGI (Y) gene during embryonic development.
    Oncogene. 1996 Dec 5;13(11):2439-46 PMID: 8957086
  18. The high mobility group protein HMG I(Y) is an essential structural component of a virus-inducible enhancer complex.
    Cold Spring Harb Symp Quant Biol. 1993;58:73-81 PMID: 7956090
  19. HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy.
    Nucleic Acids Res. 2009 Jul;37(13):4371-84 PMID: 19465398
  20. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C.
    Nature. 1995 Aug 31;376(6543):771-4 PMID: 7651535
  21. Neoplastic characteristics of the DNA found in the plasma of cancer patients.
    Oncology. 1989;46(5):318-22 PMID: 2779946
  22. Expression of high-mobility-group-protein HMGI-C mRNA in the peripheral blood is an independent poor prognostic indicator for survival in metastatic breast cancer.
    Br J Cancer. 2003 May 6;88(9):1406-10 PMID: 12778070
  23. Quantification of BRCA1 protein in sporadic breast carcinoma with or without loss of heterozygosity of the BRCA1 gene.
    Int J Cancer. 1999 Mar 15;80(6):823-6 PMID: 10074913
  24. Presence of tumor DNA in plasma of breast cancer patients: clinicopathological correlations.
    Cancer Res. 1999 Jul 1;59(13):3251-6 PMID: 10397273
  25. Tumour-specific distribution of BRCA1 promoter region methylation supports a pathogenetic role in breast and ovarian cancer.
    Carcinogenesis. 2000 Feb;21(2):147-51 PMID: 10657950
  26. Genetic heterogeneity of breast-ovarian cancer revisited. Breast Cancer Linkage Consortium.
    Am J Hum Genet. 1995 Oct;57(4):957-8 PMID: 7573057
  27. HMGA1 protein expression sensitizes cells to cisplatin-induced cell death.
    Oncogene. 2005 Oct 13;24(45):6809-19 PMID: 16007157
  28. High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.
    J Clin Invest. 2007 Mar;117(3):693-702 PMID: 17290307
  29. High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activation.
    Cancer Res. 2005 Aug 1;65(15):6622-30 PMID: 16061642
  30. SAR-dependent mobilization of histone H1 by HMG-I/Y in vitro: HMG-I/Y is enriched in H1-depleted chromatin.
    EMBO J. 1993 Aug;12(8):3237-47 PMID: 8344261
  31. Roles of HMGA proteins in cancer.
    Nat Rev Cancer. 2007 Dec;7(12):899-910 PMID: 18004397
  32. Subcellular localization of BRCA1 protein in sporadic breast carcinoma with or without allelic loss of BRCA1 gene.
    Int J Oncol. 1999 Apr;14(4):653-61 PMID: 10087311
  33. Detection of tumor messenger RNA in the serum of patients with malignant melanoma.
    Clin Cancer Res. 1999 Aug;5(8):1961-5 PMID: 10473072
  34. HMG-I(Y) recognizes base-unpairing regions of matrix attachment sequences and its increased expression is directly linked to metastatic breast cancer phenotype.
    Cancer Res. 1999 Nov 15;59(22):5695-703 PMID: 10582687
  35. The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin.
    J Biol Chem. 2000 Aug 4;275(31):23899-903 PMID: 10843985
  36. The histologic phenotypes of breast carcinoma occurring before age 40 years in women with and without BRCA1 or BRCA2 germline mutations: a population-based study.
    Cancer. 1998 Dec 1;83(11):2335-45 PMID: 9840533
Article Info
Journal
Breast care (Basel, Switzerland)
Abbr.
Breast Care (Basel)
ISSN
1661-3791
DOI
10.1159/000297717
Published
2010-00-00
Epub
2010-00-09
Pages
81-85
Language
English
Region
Switzerland
NLM ID
101254060
PMCID
PMC2931040
External Links
PubMed source DOI: 10.1159/000297717 PMC Full Text View journal details
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