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题目:: Relationship between radiation exposure and risk of second primary cancers among atomic bomb survivors.
作者:: Li(Christopher I),Nishi(Nobuo),McDougall(Jean A),Semmens(Erin O),Sugiyama(Hiromi),Soda(Midori),Sakata(Ritsu),Hayashi(Mikiko),Kasagi(Fumiyoshi),Suyama(Akihiko),Mabuchi(Kiyohiko),Davis(Scott),Kodama(Kazunori),Kopecky(Kenneth J)
状态:: 发布时间2010-09-16 , 更新时间 2016-12-03
期刊:: Cancer Res
摘要:: Radiation exposure is related to risk of numerous types of cancer, but relatively little is known about its effect on risk of multiple primary cancers. Using follow-up data through 2002 from 77,752 Japanese atomic bomb survivors, we identified 14,048 participants diagnosed with a first primary cancer, of whom 1,088 were diagnosed with a second primary cancer. Relationships between radiation exposure and risks of first and second primary cancers were quantified using Poisson regression. There was a similar linear dose-response relationship between radiation exposure and risks of both first and second primary solid tumors [excess relative risk (ERR)/Gy = 0.65; 95% confidence interval (CI), 0.57-0.74 and ERR/Gy = 0.56; 95% CI, 0.33-0.80, respectively] and risk of both first and second primary leukemias (ERR/Gy = 2.65; 95% CI, 1.78-3.78 and ERR/Gy = 3.65; 95% CI, 0.96-10.70, respectively). Background incidence rates were higher for second solid cancers, compared with first solid cancers, until about age 70 years for men and 80 years for women (P < 0.0001), but radiation-related ERRs did not differ between first and second primary solid cancers (P = 0.70). Radiation dose was most strongly related to risk of solid tumors that are radiation-sensitive including second primary lung, colon, female breast, thyroid, and bladder cancers. Radiation exposure confers equally high relative risks of second primary cancers as first primary cancers. Radiation is a potent carcinogen and those with substantial exposures who are diagnosed with a first primary cancer should be carefully screened for second primary cancers, particularly for cancers that are radiation-sensitive.
语言:: eng
DOI:

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