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PMID: 20830235 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

Skin wound healing modulation by macrophages.

International journal of clinical and experimental pathology ·Vol. 3 ·No. 7 ·2010-07-25 ·Pages 643-53

Rodero MP, Khosrotehrani K

Abstract

Skin wound healing is a multi stage phenomenon that requires the activation, recruitment or activity of numerous cell types as keratinocytes, endothelial cells, fibroblast and inflammatory cells. Among the latter, macrophages appear to be central to this process. They colonize the wound at its very early stage and in addition to their protective immune role seem to organize the activity of other cell types at the following stages of the healing. Their benefit to this process is however controversial, as macrophages are described to promote the speed of healing but may also favour the fibrosis resulting from it in scars. Moreover wound healing defects are associated with abnormalities in the inflammatory phase. In this review, we summarise our knowledge on what are the Wound Associated Macrophages, and how they interact with the other cell types to control the reepithelisation, angiogenesis and the extracellular matrix remodelling. We believe this knowledge may open new avenues for therapeutic intervention on skin wounds.

Keywords
M1 Macrophage alternatively activated cytokines growth factors healing inflammation skin wound
MeSH Terms
Animals Humans Inflammation/metabolism Macrophages/immunology,metabolism Skin/cytology,immunology,injuries Wound Healing/physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rodero Mathieu P
University of Queensland Centre for Clinical Research, Experimental Dermatology Group, Brisbane, Australia.
Khosrotehrani Kiarash
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Article Info
Journal
International journal of clinical and experimental pathology
Abbr.
Int J Clin Exp Pathol
ISSN
1936-2625
Published
2010-07-25
Epub
2010-00-25
Pages
643-53
Language
English
Region
United States
NLM ID
101480565
PMCID
PMC2933384
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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