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题目:: The elusive identity of T follicular helper cells.
作者:: Yu(Di),Vinuesa(Carola G)
状态:: 发布时间2010-10-04 , 更新时间 2010-10-04
期刊:: Trends Immunol
摘要:: Follicular helper T (Tfh) cells provide help to B cells and allow formation of long-lived antibody responses. Despite an improved understanding of the molecular program that drives Tfh cell formation, their definition remains elusive: neither follicular homing ability, Bcl-6 expression nor IL-21 secretion are exclusive properties of T cells that help B cells, and not all follicular T cells are B cell helpers. Indeed some follicular T cells appear to be suppressive. Furthermore, Tfh cells evolve during an immune response and B cells that have recently bound antigen, germinal center (GC) B cells and plasmablasts interact with phenotypically distinct Tfh cells. Here we propose that distinction between non-GC Tfh and GC Tfh cells might reconcile emerging controversies on Tfh cytokine secretion and the requirement of T-B cell interactions and SAP expression for Tfh formation.
语言:: eng
DOI:: 10.1016/j.it.2010.07.001

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