A promoting action of cyclic GMP on contractions of guinea-pig vas deferens.

Experientia ·Vol. 34 ·No. 6 ·1978-06-15 ·Pages 737-9

Wikberg JE, Andersson RG

Abstract

The effect of dbc-GMP has been studied in ductus deferens of the guinea-pig. The nucleotide potentiated the contractions induced by electrical field stimulation and by adrenergic agonists. The site of action was probably in the smooth muscle cell, since the release of excitatory transmittor was not influenced.

MeSH Terms

Animals Cyclic GMP/pharmacology Dibutyryl Cyclic GMP/pharmacology Guinea Pigs In Vitro Techniques Male Muscle Contraction/drug effects Muscle, Smooth/drug effects Norepinephrine/pharmacology Vas Deferens

Chemicals

Dibutyryl Cyclic GMP Cyclic GMP Norepinephrine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wikberg J E

Andersson R G

References (11)

11 references, click to expand

Effects of carbachol and calcium on the cyclic guanosine-3',5'-monophosphate (cyclic GMP) metabolism in intestinal smooth muscle.
Acta Physiol Scand. 1977 Feb;99(2):246-53 PMID: 14481
Alteration of vein cyclic 3':5' nucleotide concentrations during changes in contractility.
Proc Natl Acad Sci U S A. 1974 Mar;71(3):815-9 PMID: 4362635
Cyclic nucleotides and the contraction of smooth muscle.
Adv Cyclic Nucleotide Res. 1975;5:491-518 PMID: 165682
Evidence against adrenergic motor transmission in the guinea-pig vas deferens.
J Physiol. 1971 Jul;216(2):359-89 PMID: 4397760
Effects of norepinephrine on cyclic nucleotide levels in the ductus deferens of the rat.
Metabolism. 1975 Mar;24(3):429-37 PMID: 165363
The importance of calcium ions for the regulation of guanosine 3':5'-cyclic monophosphage levels.
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3889-93 PMID: 4359494
Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens.
Nature. 1977 Feb 24;265(5596):750-1 PMID: 193029
Role of muscarinic cholinergic receptors in regulation of guanosine 3':5'-cyclic monophosphate content in mammalian brain, heart muscle, and intestinal smooth muscle.
Proc Natl Acad Sci U S A. 1972 Nov;69(11):3287-91 PMID: 4343961
Radioimmunoassay for cyclic nucleotides. I. Preparation of antibodies and iodinated cyclic nucleotides.
J Biol Chem. 1972 Feb 25;247(4):1106-13 PMID: 4334491
Interrelations between cyclic AMP, cyclic GMP and contraction in guinea pig gallbladder stimulated by cholecystokinin.
Life Sci. 1977 Jan 1;20(1):73-8 PMID: 189151
A protein binding assay for adenosine 3':5'-cyclic monophosphate.
Proc Natl Acad Sci U S A. 1970 Sep;67(1):305-12 PMID: 4318781

Article Info

Journal

Experientia

Abbr.

Experientia

ISSN

0014-4754

DOI

10.1007/BF01947293

Published

1978-06-15

Pages

737-9

Language

English

Region

Switzerland

NLM ID

0376547

Subset

External Links

PubMed source DOI: 10.1007/BF01947293

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A promoting action of cyclic GMP on contractions of guinea-pig vas deferens.

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