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PMID: 2073121 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Cloning and nucleotide sequence of a chromosomally encoded tetracycline resistance determinant, tetA(M), from a pathogenic, methicillin-resistant strain of Staphylococcus aureus.

Antimicrobial agents and chemotherapy ·Vol. 34 ·No. 11 ·1990-11-00 ·Pages 2273-6

Nesin M, Svec P, Lupski JR, Godson GN, Kreiswirth B, Kornblum J, Projan SJ

Abstract

This report describes the cloning and sequencing of a chromosomally encoded tetracycline resistance determinant from a clinical isolate of methicillin-resistant Staphylococcus aureus. On the basis of the sequence, the gene is in the tet(M) class, and it was shown that the S. aureus tetA(M) gene is induced at the level of transcription.

Related Genes
tetA(M)
MeSH Terms
Amino Acid Sequence Base Sequence Blotting, Northern Chromosomes, Bacterial Cloning, Molecular Methicillin Resistance/genetics Molecular Sequence Data Staphylococcus aureus/genetics,ultrastructure Tetracycline Resistance/genetics Transcription, Genetic
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Nesin M
Department of Biochemistry, New York University Medical Center, New York 10003.
Svec P
Lupski J R
Godson G N
Kreiswirth B
Kornblum J
Projan S J
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17 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.34.11.2273
Published
1990-11-00
Pages
2273-6
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC172038
Subset
IM
Grants
NCRR NIH HHS · 507RR5399 · United States
NIGMS NIH HHS · GM-33278 · United States
NIGMS NIH HHS · GM-38292 · United States
Databases
GENBANK
M21136
External Links
PubMed source DOI: 10.1128/AAC.34.11.2273 PMC Full Text View journal details
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