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题目:: Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.
作者:: Deenick(Elissa K),Chan(Anna),Ma(Cindy S),Gatto(Dominique),Schwartzberg(Pamela L),Brink(Robert),Tangye(Stuart G)
状态:: 发布时间2010-08-24 , 更新时间 2016-11-25
期刊:: Immunity
摘要:: Effective humoral immunity depends on the support of B cell responses by T follicular helper (Tfh) cells. Although it has been proposed that Tfh cell differentiation requires T-B interactions, the relative contribution of specific populations of Ag-presenting cells remains unknown. We employed three independent strategies that compromised interactions between CD4(+) T cells and activated B cells in vivo. Whereas the expansion of CD4(+) T cells was relatively unaffected, Tfh cell differentiation was completely blocked in all scenarios. Surprisingly, augmenting antigen presentation by non-B cells rescued Tfh cell differentiation, as determined by surface phenotype, gene expression, and germinal center localization. We conclude that although Ag presentation by responding B cells is typically required for the generation of Tfh cells, this does not result from the provision of a unique B cell-derived signal, but rather because responding B cells rapidly become the primary source of antigen.
语言:: eng
DOI:

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