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PMID: 2068105 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Purification and initial characterization of the lymphoid-cell protein-tyrosine kinase p56lck from a baculovirus expression system.

Ramer SE, Winkler DG, Carrera A, Roberts TM, Walsh CT

Abstract

The lymphocyte-specific protein-tyrosine kinase p56lck has been purified 90-fold to approximately 30% purity in 30% yield from a baculovirus expression system by a two-column purification procedure. At least two forms of p56lck were isolated, differing in the extent of phosphorylation and migrating as 56- and 59-kDa species on SDS/PAGE but as a single 56-kDa band after treatment with potato acid phosphatase. Autophosphorylation of purified p56lck occurred at a rate of 25 fmol/min to a maximum incorporation of approximately 2 mol of phosphate per mol of p56lck with tyrosine-394 (but not tyrosine-505) and other, unidentified tyrosine residue(s) being the major sites of phosphorylation in vitro. Phosphorylation of tyrosine-containing peptides was monitored using an automated HPLC system. Although peptide substrate Km values were in the 1-5 mM range, the Vmax for the 13-amino acid peptide RRLIEDAEYAARG (modified p60src autophosphorylation site) was 120 min-1 (350 min-1 when adjusted for p56lck purity), suggesting that the enzyme purified from recombinant baculovirus-infected Sf9 cells has a high catalytic turnover compared with other tyrosine kinases.

MeSH Terms
Amino Acid Sequence Animals Baculoviridae/genetics Cell Line Chromatography, Affinity Electrophoresis, Polyacrylamide Gel Genetic Vectors Humans Insecta Kinetics Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Lymphocytes/enzymology Molecular Sequence Data Molecular Weight Oligopeptides/chemical synthesis,metabolism Phosphorylation Protein-Tyrosine Kinases/genetics,isolation & purification,metabolism Recombinant Proteins/isolation & purification,metabolism Substrate Specificity
Chemicals
Oligopeptides Recombinant Proteins Protein-Tyrosine Kinases Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ramer S E
Department of Biological Chemistry, Harvard Medical School, Boston, MA.
Winkler D G
Carrera A
Roberts T M
Walsh C T
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
1991-07-15
Pages
6254-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC52061
Subset
IM
Grants
NCI NIH HHS · CA43803 · United States
NIGMS NIH HHS · GM20011 · United States
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