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题目:: Distribution of CCND1 A870G polymorphism in patients with advanced uterine cervical carcinoma.
作者:: Warchoł(Teresa),Kruszyna(Lukasz),Lianeri(Margarita),Roszak(Andrzej),Jagodziński(Paweł P)
状态:: 发布时间2011-03-02 , 更新时间 2011-03-02
期刊:: Pathol Oncol Res
摘要:: We examined the distribution of the CCND1 A870G (rs9344) polymorphic variant in patients with cervical cancer (n = 129) and healthy individuals (n = 288) in a sample of a Polish cohort. We showed that patients with advanced cervical cancer bearing the CCND1 A/A and A/G genotypes displayed a 1.811-fold increased risk of cervical cancer (95% CI = 1.150-2.852, p = 0.0098). We also found a significantly higher frequency of the CCND1 870A allele in patients with cancer than in controls, p = 0.0116. Our investigation confirmed that the CCND1 870A gene variant may be a genetic risk factor in the incidence of advanced cervical cancer.
语言:: eng
DOI:: 10.1007/s12253-010-9293-3

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