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PMID: 20651165 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Resolved: EMT produces fibroblasts in the kidney.

Journal of the American Society of Nephrology : JASN ·Vol. 21 ·No. 8 ·2010-08-00 ·Pages 1247-53

Zeisberg M, Duffield JS

Abstract

Epithelial-mesenchymal transition (EMT) is a mechanism for generating primitive mesenchymal cells during gastrulation or mobile tumor cells during cancer metastasis. For 15 years, EMT has also been viewed as a principal source of fibroblasts in tissue fibrosis. Because several recent studies question its role in fibrogenesis, it seems like a good time for debate.

MeSH Terms

Animals Cell Differentiation Epithelial Cells/cytology Fibroblasts/cytology Humans Kidney/cytology Mesoderm/cytology

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Zeisberg Michael

Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. mzeisber@bidmc.harvard.edu

Duffield Jeremy S

Article Info

Journal

Journal of the American Society of Nephrology : JASN

Abbr.

J Am Soc Nephrol

ISSN

1533-3450

DOI

10.1681/ASN.2010060616

mzeisber@bidmc.harvard.edu

Published

2010-08-00

Epub

2010-00-22

Pages

1247-53

Language

English

Region

United States

NLM ID

9013836

Subset

Grants

NIDDK NIH HHS · DK73299 · United States

NIDDK NIH HHS · DK84077 · United States

NIDDK NIH HHS · DK87389 · United States

NIDDK NIH HHS · K08DK074558 · United States

NIDDK NIH HHS · R01DK081576 · United States

NIDDK NIH HHS · R03DK081687 · United States

External Links

PubMed source DOI: 10.1681/ASN.2010060616 View journal details

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Resolved: EMT produces fibroblasts in the kidney.

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