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题目:: Amplification of IGH/CCND1 fusion gene in a primary plasma cell leukemia case.
作者:: Ishigaki(Tomohiro),Sasaki(Kouji),Watanabe(Ken),Nakamura(Norihiko),Toyota(Shigeo),Kobayashi(Hirofumi),Tohda(Shuji)
状态:: 发布时间2010-07-16 , 更新时间 2010-07-16
期刊:: Cancer Genet Cytogenet
摘要:: The IGH/CCND1 fusion gene has been reported in many hematologic tumors such as mantle cell lymphoma, chronic lymphocytic leukemia, prolymphocytic leukemia, multiple myeloma, and plasma cell leukemia. We report a case of plasma cell leukemia showing five IGH/CCND1 fusion signals by interphase fluorescence in situ hybridization (FISH). Conventional cytogenetic analysis and multicolor spectral karyotyping showed a complex karyotype that did not include t(11;14). Metaphase FISH studies revealed three IGH/CCND1 fusion signals, two of which were amplified signals. These findings indicate that IGH/CCND1 fusion gene was amplified and interspersed in several chromosomes. The patient was treated with intensive chemotherapy. However, the clinical course was very aggressive. The amplification of the IGH/CCND1 fusion gene may contribute to the aggressive course of the disease. To our knowledge, this is the first case showing amplification of the IGH/CCND1 gene in plasma cell neoplasms.
语言:: eng
DOI:: 10.1016/j.cancergencyto.2010.05.006

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