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题目:: Bone marrow stromal cell line promotes the proliferation of mast cell progenitors derived from cord blood CD34+ cells under serum-free conditions with a combination of both cell-cell interaction and soluble factors.
作者:: Fujihara(Mitsuhiro),Azuma(Hiroshi),Ikeda(Hisami),Yamaguchi(Miki),Hamada(Hirofumi)
状态:: 发布时间2011-03-07 , 更新时间 2012-11-15
期刊:: Artif Cells Blood Substit Immobil Biotechnol
摘要:: A higher production of functional mast cells (MCs) can be generated by co-culturing cord blood-derived CD34+ cells with a human bone marrow stromal cell line under serum-free conditions supplemented with stem cell factor and IL-6. We addressed the question of whether the higher proliferation of MCs in this co-culture system might be due to the higher proliferation of MC progenitors. The stromal cell line increased the cell numbers of MC progenitors derived from cord blood-derived CD34+ cells, in a combination of cell-cell interactions between stromal cells and CD34+ cells, and as yet unidentified soluble factors derived from stromal cells.
语言:: eng
DOI:: 10.3109/10731199.2010.501754

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