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PMID: 20620114 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Neutrophil kinetics in health and disease.

Trends in immunology ·Vol. 31 ·No. 8 ·2010-08-00 ·Pages 318-24

Summers C, Rankin SM, Condliffe AM, Singh N, Peters AM, Chilvers ER

Abstract

Neutrophils play a key role in the elimination of pathogens. They are remarkably short-lived with a circulating half life of 6-8h and hence are produced at a rate of 5x10(10)-10x10(10) cells/day. Tight regulation of these cells is vital because they have significant histotoxic capacity and are widely implicated in tissue injury. This review outlines our current understanding of how neutrophils are released from the bone marrow; in particular, the role of the CXC chemokine receptor 4/stromal-derived factor 1 axis, the relative size and role of the freely circulating and marginated (i.e. slowly transiting) pools within the vascular compartment, and the events that result in the uptake and removal of circulating neutrophils. We also review current understanding of how systemic stress and inflammation affect this finely balanced system.

MeSH Terms
Animals Cell Movement Chemokine CXCL12/immunology Humans Kinetics Neutrophils/cytology,immunology Receptors, CXCR4/immunology
Chemicals
Chemokine CXCL12 Receptors, CXCR4
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Summers Charlotte
Department of Medicine, University of Cambridge School of Medicine, UK.
Rankin Sara M
Condliffe Alison M
Singh Nanak
Peters A Michael
Chilvers Edwin R
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Article Info
Journal
Trends in immunology
Abbr.
Trends Immunol
ISSN
1471-4981
DOI
10.1016/j.it.2010.05.006
Published
2010-08-00
Pages
318-24
Language
English
Region
England
NLM ID
100966032
PMCID
PMC2930213
Subset
IM
Grants
Wellcome Trust · 077940 · United Kingdom
Medical Research Council · MR/J00345X/1 · United Kingdom
External Links
PubMed source DOI: 10.1016/j.it.2010.05.006 PMC Full Text View journal details
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