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题目:: Direct, help-independent priming of CD8+ T cells by adeno-associated virus-transduced hepatocytes.
作者:: Wuensch(Sherry A),Spahn(Jessica),Crispe(Ian N)
状态:: 发布时间2010-09-02 , 更新时间 2016-11-22
期刊:: Hepatology
摘要:: Both hepatitis B and C viruses frequently establish chronic infection, raising the question whether T cells are poorly primed in the liver. To determine the role of different cell types in the activation of CD8+ T cells against hepatocellular antigens, we used an Adeno-associated virus to deliver ovalbumin to hepatocytes. In contrast to CD8+ T cells, CD4+ T cells were not activated. The CD8+ T cells were activated even in the absence of endogenous CD4+ T cells; however, in the liver, these cells were high in the programmed death-1 protein and low in CD127. Chimera experiments revealed that these CD8+ T cells were activated on a solid tissue cell.,Priming of CD8+ T cells directly on nonhematopoietic cells, in the absence of CD4+ T cell help, results in suboptimal T cell activation. This could explain the impaired function of CD8+ T cells seen in chronic liver infection.
语言:: eng
DOI:

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