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PMID: 20575659 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Increased level of arginase activity correlates with disease severity in HIV-seropositive patients.

The Journal of infectious diseases ·Vol. 202 ·No. 3 ·2010-08-15 ·Pages 374-85

Cloke TE, Garvey L, Choi BS, Abebe T, Hailu A, Hancock M, Kadolsky U, Bangham CR, Munder M, Müller I, Taylor GP, Kropf P

Abstract

Infection with human immunodeficiency virus (HIV) results in a chronic infection that progressively impairs the immune system. Although depletion of CD4(+) T cells is frequently used to explain immunosuppression, chronicity of infection and progressive loss of CD4(+) T cells are not sufficient to fully account for immune dysregulation. Arginase-induced l-arginine deprivation is emerging as a key mechanism for the down-regulation of immune responses. Here, we hypothesized that the level of arginase activity increases with disease severity in HIV-seropositive patients. We determined the levels of arginase activity in peripheral blood mononuclear cells from HIV-seropositive patients and uninfected control participants. Our results show that peripheral blood mononuclear cells from HIV-seropositive patients with low CD4(+) T cell counts expressed statistically significantly higher levels of arginase activity, compared with patients with high CD4(+) T cell counts or uninfected control participants. Furthermore, we found a statistically significant correlation between high level of arginase activity and high viral load in HIV-seropositive patients.

MeSH Terms
Adult Arginase/metabolism CD4 Lymphocyte Count Cells, Cultured Female HIV/isolation & purification HIV Infections/immunology,pathology Humans Leukocytes, Mononuclear/enzymology Male Middle Aged Severity of Illness Index Viral Load
Chemicals
Arginase
Authors & Affiliations
12 authors, click to expand affiliations / ORCID
Cloke T E
Department of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom.
Garvey L
Choi B-S
Abebe T
Hailu A
Hancock M
Kadolsky U
Bangham C R M
Munder M
Müller I
Taylor G P
Kropf P
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Article Info
Journal
The Journal of infectious diseases
Abbr.
J Infect Dis
ISSN
1537-6613
Published
2010-08-15
Pages
374-85
Language
English
Region
United States
NLM ID
0413675
PMCID
PMC4663662
Subset
IM
Grants
Wellcome Trust · United Kingdom
Wellcome Trust · 089201 · United Kingdom
Wellcome Trust · 07664/Z/05/Z · United Kingdom
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