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PMID: 20561775 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Cell biology of Ca2+-triggered exocytosis.

Current opinion in cell biology ·Vol. 22 ·No. 4 ·2010-08-00 ·Pages 496-505

Pang ZP, Südhof TC

Abstract

Ca(2+) triggers many forms of exocytosis in different types of eukaryotic cells, for example synaptic vesicle exocytosis in neurons, granule exocytosis in mast cells, and hormone exocytosis in endocrine cells. Work over the past two decades has shown that synaptotagmins function as the primary Ca(2+)-sensors for most of these forms of exocytosis, and that synaptotagmins act via Ca(2+)-dependent interactions with both the fusing phospholipid membranes and the membrane fusion machinery. However, some forms of Ca(2+)-induced exocytosis may utilize other, as yet unidentified Ca(2+)-sensors, for example, slow synaptic exocytosis mediating asynchronous neurotransmitter release. In the following overview, we will discuss the synaptotagmin-based mechanism of Ca(2+)-triggered exocytosis in neurons and neuroendocrine cells, and its potential extension to other types of Ca(2+)-stimulated exocytosis for which no synaptotagmin Ca(2+)-sensor has been identified.

MeSH Terms
Animals Calcium/metabolism Cells/metabolism Exocytosis Humans Models, Biological Synapses/metabolism Synaptotagmins/metabolism
Chemicals
Synaptotagmins Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pang Zhiping P
Department of Molecular and Cellular Physiology, Stanford University, 1050 Arastradero Rd., Palo Alto, CA 94304-5543, USA. zpang@stanford.edu
Südhof Thomas C
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
1879-0410
DOI
10.1016/j.ceb.2010.05.001
Email
zpang@stanford.edu
Published
2010-08-00
Epub
2010-00-03
Pages
496-505
Language
English
Region
England
NLM ID
8913428
PMCID
PMC2963628
Subset
IM
Grants
Howard Hughes Medical Institute · United States
NINDS NIH HHS · T32 NS007280 · United States
NINDS NIH HHS · 5T32NS007280 · United States
External Links
PubMed source DOI: 10.1016/j.ceb.2010.05.001 PMC Full Text View journal details
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