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PMID: 20550891 Published · ppublish English Journal Article

A model of fibroblast motility on substrates with different rigidities.

Biophysical journal ·Vol. 98 ·No. 12 ·2010-06-16 ·Pages 2794-803

Dokukina IV, Gracheva ME

Abstract

To function efficiently in the body, the biological cells must have the ability to sense the external environment. Mechanosensitivity toward the extracellular matrix was identified as one of the sensing mechanisms affecting cell behavior. It was shown experimentally that a fibroblast cell prefers locomoting over the stiffer substrate when given a choice between a softer and a stiffer substrate. In this article, we develop a discrete model of fibroblast motility with substrate-rigidity sensing. Our model allows us to understand the interplay between the cell-substrate sensing and the cell biomechanics. The model cell exhibits experimentally observed substrate rigidity sensing, which allows us to gain additional insights into the cell mechanosensitivity.

MeSH Terms
Biomechanical Phenomena Cell Movement Fibroblasts/cytology Kinetics Models, Biological
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dokukina Irina V
Department of Physics, Clarkson University, Potsdam, New York, USA.
Gracheva Maria E
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
1542-0086
DOI
10.1016/j.bpj.2010.03.026
Published
2010-06-16
Pages
2794-803
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC2884250
Subset
IM
Corrections
ErratumIn
-
ErratumIn
PMID: 30021262
External Links
PubMed source DOI: 10.1016/j.bpj.2010.03.026 PMC Full Text View journal details
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