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PMID: 20534708 Published · ppublish English Journal Article Review

Navigating intermediate targets: the nervous system midline.

Cold Spring Harbor perspectives in biology ·Vol. 2 ·No. 8 ·2010-08-00 ·Pages a002055

Dickson BJ, Zou Y

Abstract

In a bilaterally symmetric animal, the midline plays a key role in directing axon growth during wiring of the nervous system. Midline cells provide a variety of guidance cues for growing axons, to which different types of axons respond in different ways and at different times. For some axons, the midline is an intermediate target. They first seek it out, but then move on towards their final targets on the opposite side. For others, the midline is a repulsive barrier that keeps them on their own side of the midline. And for many of these axons the midline provides signals that guide them along specific lateral pathways or up and down the longitudinal axis.

MeSH Terms
Animals Axons/physiology Body Patterning Chick Embryo Developmental Biology/methods Drosophila Humans Mice Microscopy, Confocal/methods Models, Biological Models, Neurological Nervous System
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dickson Barry J
Research Institute of Molecular Pathology, Dr. Bohrgasse 7, A-1030 Vienna, Austria. dickson@imp.ac.at
Zou Yimin
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Article Info
Journal
Cold Spring Harbor perspectives in biology
Abbr.
Cold Spring Harb Perspect Biol
ISSN
1943-0264
DOI
10.1101/cshperspect.a002055
Email
dickson@imp.ac.at
Published
2010-08-00
Epub
2010-00-09
Pages
a002055
Language
English
Region
United States
NLM ID
101513680
PMCID
PMC2908764
Subset
IM
Grants
NINDS NIH HHS · R01 NS047484 · United States
External Links
PubMed source DOI: 10.1101/cshperspect.a002055 PMC Full Text View journal details
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