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PMID: 20513517 Published · ppublish English Journal Article Review

The role of viruses in acute exacerbations of asthma.

The Journal of allergy and clinical immunology ·Vol. 125 ·No. 6 ·2010-06-00 ·Pages 1178-87; quiz 1188-9

Jackson DJ, Johnston SL

Abstract

Viral respiratory infections are the most common cause of an acute asthma exacerbation in both children and adults and represent a significant global health burden. An increasing body of evidence supports the hypothesis that these infections cause a greater degree of morbidity in asthmatic subjects than in the healthy population, emphasizing a discrepancy in the antiviral response of asthmatics. In this review we discuss why such a discrepancy might exist, examining the role of the bronchial epithelium as well as the main inflammatory cells, mediators, and molecular pathways that are involved in the immune response. In addition, the potential impact of virus-induced asthma exacerbations on airway remodelling is reviewed and we explore which therapeutic options might be of benefit in preventing the deterioration of asthma control seen following viral infection.

MeSH Terms
Adrenal Cortex Hormones/therapeutic use Adrenergic beta-Agonists/therapeutic use Adult Airway Remodeling/immunology Asthma/etiology,immunology,therapy Child Humans Immunity Inflammation Mediators/immunology NF-kappa B/immunology Picornaviridae Infections/complications,immunology,therapy Respiratory Mucosa/immunology Respiratory Tract Infections/complications,immunology,therapy Rhinovirus/immunology,pathogenicity Signal Transduction/immunology
Chemicals
Adrenal Cortex Hormones Adrenergic beta-Agonists Inflammation Mediators NF-kappa B
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jackson David J
Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom. d.jackson@imperial.ac.uk
Johnston Sebastian L
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Article Info
Journal
The Journal of allergy and clinical immunology
Abbr.
J Allergy Clin Immunol
ISSN
1097-6825
DOI
10.1016/j.jaci.2010.04.021
Email
d.jackson@imperial.ac.uk
Published
2010-06-00
Pages
1178-87; quiz 1188-9
Language
English
Region
United States
NLM ID
1275002
PMCID
PMC7172767
Subset
IM
External Links
PubMed source DOI: 10.1016/j.jaci.2010.04.021 PMC Full Text View journal details
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