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PMID: 2050424 Published · ppublish English Clinical Trial Comparative Study Journal Article Randomized Controlled Trial

Ofloxacin versus trimethoprim-sulfamethoxazole for prevention of infection in patients with acute leukemia and granulocytopenia.

Infection ·Vol. 19 ·No. 2 ·1991-00-00 ·Pages 73-80

Kern W, Kurrle E

Abstract

In a prospective randomized study we evaluated the efficacy and safety of oral ofloxacin (dosage: 200 mg three times daily) versus trimethoprim-sulfamethoxazole (dosage: 960 mg three times daily) as antibacterial prophylaxis in 128 patients with acute leukemia who received aggressive cytotoxic chemotherapy and were granulocytopenic for a median duration of 30 days. Fewer patients receiving ofloxacin were colonized by Enterobacteriaceae (13% versus 90%, p less than 0.001) and Pseudomonas aeruginosa (3% versus 14%, p = 0.025), and developed gram-negative bacterial infection (4% versus 26%, p = 0.002), whereas the incidence of gram-positive bacterial (19% versus 22%) and fungal (7% versus 14%) infections was similar in both groups. Ofloxacin was significantly better tolerated than trimethoprim-sulfamethoxazole, and shortened the duration of fever (p = 0.02) and of parenteral antimicrobial therapy for presumed or documented acquired infection (p = 0.01). Ofloxacin appears to be a safe, effective, well-tolerated alternative to trimethoprim-sulfamethoxazole for preventing gram-negative infection in acute leukemia, but more effective prophylaxis of gram-positive infections is still needed.

MeSH Terms
Acute Disease Administration, Oral Adolescent Adult Aged Agranulocytosis/complications Bacterial Infections/prevention & control Female Gram-Negative Bacteria/isolation & purification Gram-Positive Bacteria/isolation & purification Humans Leukemia, Myeloid/complications Male Middle Aged Ofloxacin/therapeutic use Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications Prospective Studies Remission Induction Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use
Chemicals
Trimethoprim, Sulfamethoxazole Drug Combination Ofloxacin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kern W
Medizinische Universitätsklinik, Ulm, Germany.
Kurrle E
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51 references, click to expand
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Article Info
Journal
Infection
Abbr.
Infection
ISSN
0300-8126
DOI
10.1007/BF01645571
Published
1991-00-00
Pages
73-80
Language
English
Region
Germany
NLM ID
0365307
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01645571 View journal details
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