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PMID: 20444740 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Hypoxic regulation of erythropoiesis and iron metabolism.

American journal of physiology. Renal physiology ·Vol. 299 ·No. 1 ·2010-07-00 ·Pages F1-13

Haase VH

Abstract

The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the hypoxic induction of red blood cell production. Efforts to understand the molecular basis of oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which is essential for normal erythropoiesis and to the purification of hypoxia-inducible factor (HIF), the transcription factor that regulates EPO synthesis and mediates cellular adaptation to hypoxia. Recent insights into the molecular mechanisms that control and integrate cellular and systemic erythropoiesis-promoting hypoxia responses and their potential as a therapeutic target for the treatment of renal anemia are discussed in this review.

MeSH Terms
Anemia/blood,drug therapy,genetics Animals Basic Helix-Loop-Helix Transcription Factors/genetics,metabolism Bone Marrow/metabolism Erythrocytes/drug effects,metabolism Erythropoiesis/drug effects,genetics Erythropoietin/biosynthesis,blood,genetics Gene Expression Regulation Hematinics/therapeutic use Homeostasis Humans Hypoxia/blood,genetics Iron/blood Kidney/metabolism Oxygen/blood Polycythemia/blood,genetics Procollagen-Proline Dioxygenase/genetics,metabolism Protein Processing, Post-Translational Von Hippel-Lindau Tumor Suppressor Protein/blood,genetics
Chemicals
Basic Helix-Loop-Helix Transcription Factors Hematinics Erythropoietin endothelial PAS domain-containing protein 1 Iron Procollagen-Proline Dioxygenase Von Hippel-Lindau Tumor Suppressor Protein Oxygen
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Haase Volker H
Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA. volker.haase@vanderbilt.edu
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Article Info
Journal
American journal of physiology. Renal physiology
Abbr.
Am J Physiol Renal Physiol
ISSN
1522-1466
DOI
10.1152/ajprenal.00174.2010
Email
volker.haase@vanderbilt.edu
Published
2010-07-00
Epub
2010-00-05
Pages
F1-13
Language
English
Region
United States
NLM ID
100901990
PMCID
PMC2904169
Subset
IM
Grants
NIDDK NIH HHS · R01 DK080821 · United States
NIDDK NIH HHS · R01 DK081646 · United States
External Links
PubMed source DOI: 10.1152/ajprenal.00174.2010 PMC Full Text View journal details
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