Cancer genomics identifies determinants of tumor biology.

Genome biology ·Vol. 11 ·No. 5 ·2010-00-00 ·Pages 211

Mardis ER

Abstract

Unbiased sequencing and analysis of human tumors is revealing unsuspected somatic changes that, upon further study, are elucidating aspects of tumor biology and identifying new biomarkers.

MeSH Terms

Biomarkers, Tumor/genetics,metabolism Gene Expression Profiling Genome, Human/genetics Genomics/methods Humans Neoplasm Metastasis/genetics Neoplasms/genetics

Chemicals

Biomarkers, Tumor

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Mardis Elaine R

The Genome Center, Washington University School of Medicine, St Louis, MO 63108, USA. emardis@wustl.edu

References (26)

26 references, click to expand

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.
Acta Neuropathol. 2009 Oct;118(4):469-74 PMID: 19554337
Loss of CSMD1 expression is associated with high tumour grade and poor survival in invasive ductal breast carcinoma.
Breast Cancer Res Treat. 2010 Jun;121(3):555-63 PMID: 19669408
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations.
J Exp Med. 2010 Feb 15;207(2):339-44 PMID: 20142433
A turning point in cancer research: sequencing the human genome.
Science. 1986 Mar 7;231(4742):1055-6 PMID: 3945817
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
Cancer Cell. 2010 Mar 16;17(3):225-34 PMID: 20171147
An integrated genomic analysis of human glioblastoma multiforme.
Science. 2008 Sep 26;321(5897):1807-12 PMID: 18772396
Induced chromosomal proximity and gene fusions in prostate cancer.
Science. 2009 Nov 27;326(5957):1230 PMID: 19933109
Transcriptome sequencing to detect gene fusions in cancer.
Nature. 2009 Mar 5;458(7234):97-101 PMID: 19136943
Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells.
J Biol Chem. 2009 Jul 3;284(27):18252-9 PMID: 19458087
Recurring mutations found by sequencing an acute myeloid leukemia genome.
N Engl J Med. 2009 Sep 10;361(11):1058-66 PMID: 19657110
Mutation of FOXL2 in granulosa-cell tumors of the ovary.
N Engl J Med. 2009 Jun 25;360(26):2719-29 PMID: 19516027
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.
Science. 2009 Apr 10;324(5924):261-5 PMID: 19359588
Target-enrichment strategies for next-generation sequencing.
Nat Methods. 2010 Feb;7(2):111-8 PMID: 20111037
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution.
Nature. 2009 Oct 8;461(7265):809-13 PMID: 19812674
On the origin of cancer cells.
Science. 1956 Feb 24;123(3191):309-14 PMID: 13298683
Chimeric transcript discovery by paired-end transcriptome sequencing.
Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12353-8 PMID: 19592507
BreakDancer: an algorithm for high-resolution mapping of genomic structural variation.
Nat Methods. 2009 Sep;6(9):677-81 PMID: 19668202
Analysis of the IDH1 codon 132 mutation in brain tumors.
Acta Neuropathol. 2008 Dec;116(6):597-602 PMID: 18985363
Genome remodelling in a basal-like breast cancer metastasis and xenograft.
Nature. 2010 Apr 15;464(7291):999-1005 PMID: 20393555
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Nature. 2009 Dec 10;462(7274):739-44 PMID: 19935646
IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas.
Am J Pathol. 2009 Apr;174(4):1149-53 PMID: 19246647
Reconstruction of functionally normal and malignant human breast tissues in mice.
Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4966-71 PMID: 15051869
Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity.
J Biol Chem. 2004 Aug 6;279(32):33946-57 PMID: 15173171
IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors.
Hum Mutat. 2009 Jan;30(1):7-11 PMID: 19117336
IDH1 and IDH2 mutations in gliomas.
N Engl J Med. 2009 Feb 19;360(8):765-73 PMID: 19228619
Development of personalized tumor biomarkers using massively parallel sequencing.
Sci Transl Med. 2010 Feb 24;2(20):20ra14 PMID: 20371490

Article Info

Journal

Genome biology

Abbr.

Genome Biol

ISSN

1474-760X

DOI

10.1186/gb-2010-11-5-211

emardis@wustl.edu

Published

2010-00-00

Epub

2010-00-05

Pages

211

Language

English

Region

England

NLM ID

100960660

PMCID

PMC2898082

Subset

External Links

PubMed source DOI: 10.1186/gb-2010-11-5-211 PMC Full Text View journal details

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Cancer genomics identifies determinants of tumor biology.

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