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PMID: 20439426 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

The JARID2-PRC2 duality.

Genes & development ·Vol. 24 ·No. 9 ·2010-05-00 ·Pages 857-61

Herz HM, Shilatifard A

Abstract

Polycomb group proteins (PcG) are required for proper developmental regulation and cell fate commitment in metazoans. Recently, four studies reported the identification of JARID2, a JmjC domain-containing protein, as a component of the Polycomb-repressive complex 2 (PRC2), which is involved in implementing histone H3 Lys 27 methylation and transcriptional repression during development. Here, we discuss the implications of these studies for an improved understanding of PcG function in development.

MeSH Terms
Animals Drosophila Proteins/metabolism Gene Expression Regulation Gene Silencing Histone-Lysine N-Methyltransferase/metabolism Humans Mice Nerve Tissue Proteins/metabolism
Chemicals
Drosophila Proteins Nerve Tissue Proteins Histone-Lysine N-Methyltransferase PRC2 protein, Drosophila
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Herz Hans-Martin
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
Shilatifard Ali
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
1549-5477
DOI
10.1101/gad.1921610
Published
2010-05-00
Pages
857-61
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC2861184
Subset
IM
Grants
NCI NIH HHS · R01 CA089455 · United States
NCI NIH HHS · R01CA89455 · United States
NIGMS NIH HHS · R01GM069905 · United States
NCI NIH HHS · R01CA150265 · United States
NCI NIH HHS · R01 CA150265 · United States
NIGMS NIH HHS · R01 GM069905 · United States
External Links
PubMed source DOI: 10.1101/gad.1921610 PMC Full Text View journal details
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