Epigenetics drives RAGs to recombination riches.

Cell ·Vol. 141 ·No. 3 ·2010-04-30 ·Pages 400-2

Schlissel MS

Abstract

V(D)J recombination of antigen receptor gene segments in B and T cells is mediated by the lymphoid-specific proteins RAG1 and RAG2. Now, Ji et al. (2010) demonstrate how RAG1 and RAG2 use DNA sequence specificity and modified histones within chromatin to target specific loci for V(D)J recombination at different stages of lymphoid development.

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Schlissel Mark S

Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA. mss@berkeley.edu

Article Info

Journal

Cell

Abbr.

Cell

ISSN

1097-4172

DOI

10.1016/j.cell.2010.04.014

mss@berkeley.edu

Published

2010-04-30

Pages

400-2

Language

English

Region

United States

NLM ID

0413066

Corrections

CommentOn

PMID: 20398922

External Links

PubMed source DOI: 10.1016/j.cell.2010.04.014 View journal details

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Epigenetics drives RAGs to recombination riches.

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