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PMID: 20431620 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor critically dependent on IFN-gamma signaling during acute malaria.

Nature immunology ·Vol. 11 ·No. 6 ·2010-06-00 ·Pages 477-85

Belyaev NN, Brown DE, Diaz AI, Rae A, Jarra W, Thompson J, Langhorne J, Potocnik AJ

Abstract

Although the relationship between hematopoietic stem cells and progenitor populations has been investigated extensively under steady-state conditions, the dynamic response of the hematopoietic compartment during acute infection is largely unknown. Here we show that after infection of mice with Plasmodium chabaudi, a c-Kit(hi) progenitor subset positive for interleukin 7 receptor-alpha (IL-7Ralpha) emerged that had both lymphoid and myeloid potential in vitro. After being transferred into uninfected alymphoid or malaria-infected hosts, IL-7Ralpha(+)c-Kit(hi) progenitors generated mainly myeloid cells that contributed to the clearance of infected erythrocytes in infected hosts. The generation of these infection-induced progenitors was critically dependent on interferon-gamma (IFN-gamma) signaling in hematopoietic progenitors. Thus, IFN-gamma is a key modulator of hematopoiesis and innate and adaptive immunity during acute malaria infection.

MeSH Terms
Adaptive Immunity Animals Hematopoietic Stem Cells/immunology Humans Immunity, Innate Interferon-gamma/immunology Malaria/immunology Mice Myeloid Progenitor Cells/immunology Plasmodium chabaudi Proto-Oncogene Proteins c-kit/immunology Receptors, Interleukin-7/immunology Signal Transduction T-Lymphocyte Subsets/immunology
Chemicals
Receptors, Interleukin-7 Interferon-gamma Proto-Oncogene Proteins c-kit
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Belyaev Nikolai N
Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London, UK.
Brown Douglas E
Diaz Ana-Isabel Garcia
Rae Aaron
Jarra William
Thompson Joanne
Langhorne Jean
Potocnik Alexandre J
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Article Info
Journal
Nature immunology
Abbr.
Nat Immunol
ISSN
1529-2916
DOI
10.1038/ni.1869
Published
2010-06-00
Epub
2010-00-02
Pages
477-85
Language
English
Region
United States
NLM ID
100941354
Subset
IM
Grants
Medical Research Council · MC_U117584248 · United Kingdom
Medical Research Council · MC_U117565359 · United Kingdom
Medical Research Council · U117569359 · United Kingdom
Medical Research Council · G0600845 · United Kingdom
Medical Research Council · U117584248 · United Kingdom
External Links
PubMed source DOI: 10.1038/ni.1869 View journal details
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