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PMID: 2043103 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Mastoparan induces oscillations of cytosolic Ca2+ in rat pancreatic acinar cells.

Biochemical and biophysical research communications ·Vol. 177 ·No. 1 ·1991-05-31 ·Pages 159-65

Yule DI, Williams JA

Abstract

Microfluorimetry of fura-2 was used to monitor [Ca2+]i in single cells stimulated with the G-protein activating agent mastoparan. Mastoparan induced the generation of [Ca2+]i oscillations, which in contrast to oscillations induced by low concentrations of CCK were acutely dependent on the presence of extracellular Ca2+. Oscillations were inhibited by phorbol ester. Sodium fluoride, a known activator of G-proteins, gave similar results. Both mastoparan and CCK induced turnover of inositol phosphates, at concentrations higher than necessary to induce oscillations.

MeSH Terms
Alkaloids/pharmacology Animals Calcium/metabolism Cholecystokinin/pharmacology Cytosol/drug effects,metabolism In Vitro Techniques Inositol Phosphates/metabolism Intercellular Signaling Peptides and Proteins Kinetics Male Microscopy, Fluorescence Pancreas/cytology,drug effects,metabolism Peptides Protein Kinase C/antagonists & inhibitors,metabolism Rats Sodium Fluoride/pharmacology Staurosporine Tetradecanoylphorbol Acetate/pharmacology Time Factors Wasp Venoms/pharmacology
Chemicals
Alkaloids Inositol Phosphates Intercellular Signaling Peptides and Proteins Peptides Wasp Venoms mastoparan Sodium Fluoride Cholecystokinin Protein Kinase C Staurosporine Tetradecanoylphorbol Acetate Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Yule D I
Department of Physiology, University of Michigan Ann Arbor 48109-0622.
Williams J A
Article Info
Journal
Biochemical and biophysical research communications
Abbr.
Biochem Biophys Res Commun
ISSN
0006-291X
DOI
10.1016/0006-291x(91)91962-c
Published
1991-05-31
Pages
159-65
Language
English
Region
United States
NLM ID
0372516
Subset
IM
Grants
NIDDK NIH HHS · DK-41122 · United States
External Links
PubMed source DOI: 10.1016/0006-291x(91)91962-c View journal details
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