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题目:: The relationship of chronic lymphocytic leukemia to normal activated B cells.
作者:: Freedman(A S),Nadler(L M)
状态:: 发布时间2010-04-16 , 更新时间 2010-04-16
期刊:: Leuk Lymphoma
摘要:: There is compelling evidence that B-CLL cells are neoplastic counterparts of minor sub-populations of normal B cells. These normal cells include populations of activated B cells. The cell surface phenotype of B-CLL cells, characterized by the lack of several antigens (Ags) present on mature resting B cells and the presence of Ags preferentially expressed on activated B cells supports this hypothesis. Although controversial, B-CLLs are capable of responding in vitro to a variety of growth and differentiation factors which stimulate the proliferation and immunoglobulin secretion of normal activated B cells. These findings coupled with the observations that B-CLL cells produce cytokines which are normally secreted by stimulated B cells provide further evidence for the similarity between normal activated B cells and B-CLL cells.
语言:: eng
DOI:: 10.1080/10428199009169598

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