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PMID: 203930 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Specific regulation by steroid hormones of the amount of type I cyclic AMP-dependent protein kinase holoenzyme.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 1 ·1978-01-00 ·Pages 223-7

Fuller DJ, Byus CV, Russell DH

Abstract

The total amounts of type I and type II cytoplasmic cyclic AMP-dependent protein kinase activities were measured in various tissues of intact rats and rats subjected to castration, hypophysectomy, or adrenalectomy. After castration, the total amount of type I activity decreased rapidly in classifically steroid-responsive tissues such as the ventral prostate and levator ani muscle and less rapidly in the liver. After hypophysectomy and adrenalectomy, type I activity in the liver decreased to the same extent as after castration. Type I activity could be maintained in the ventral prostate and levator ani muscle at control levels by the daily injection of dihydrotestosterone. Furthermore, after post-castration regression of the prostate for 3 days, three daily subcutaneous injections of dihydrotestosterone resulted in a complete restoration of type I activity toe the intact level. The amount of type II activity was not altered by any of the experimental ablations. This study provides evidence linking steroid action to the ability of steroid-responsive tissues to maintain a substantial activity of type I cyclic AMP-dependent protein kinase.

MeSH Terms

Adrenalectomy Animals Castration Cyclic AMP/metabolism Hormones/physiology Hypophysectomy Isoenzymes/metabolism Liver/enzymology Male Muscles/enzymology Prostate/enzymology Protein Kinases/metabolism Rats

Chemicals

Hormones Isoenzymes Cyclic AMP Protein Kinases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Fuller D J

Byus C V

Russell D H

References (21)

21 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.75.1.223

Published

1978-01-00

Pages

223-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC411218

Subset

External Links

PubMed source DOI: 10.1073/pnas.75.1.223 PMC Full Text View journal details

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Specific regulation by steroid hormones of the amount of type I cyclic AMP-dependent protein kinase holoenzyme.

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