On the potential of natural products in the discovery of pharma leads: a case for reassessment.

Natural product reports ·Vol. 27 ·No. 8 ·2010-08-00 ·Pages 1114-6

Danishefsky S

Abstract

The central proposition advanced herein is that complex target oriented synthesis, enabled by historic advances in methodology, has enormously expanded the scope of the possible. Accordingly, natural products, a proven long-term source of pharma discovery, re-emerge as potentially valuable elements for synthesis-driven pharma exploitation.

MeSH Terms

Animals Biological Products/chemical synthesis,chemistry,pharmacology Drug Discovery Epothilones/chemical synthesis,chemistry,pharmacology Macrolides/chemical synthesis,chemistry,pharmacology Mice Molecular Structure Myxococcales/chemistry Piperidones/chemical synthesis,chemistry,pharmacology Streptomyces/chemistry

Chemicals

Biological Products Epothilones Macrolides Piperidones migrastatin

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Danishefsky Samuel

Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

Article Info

Journal

Natural product reports

Abbr.

Nat Prod Rep

ISSN

1460-4752

DOI

10.1039/c003211p

Published

2010-08-00

Epub

2010-00-09

Pages

1114-6

Language

English

Region

England

NLM ID

8502408

Subset

External Links

PubMed source DOI: 10.1039/c003211p View journal details

Analysis Services

On the potential of natural products in the discovery of pharma leads: a case for reassessment.

Contact

WeChat Official Account