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PMID: 20375160 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

The ABCs of rhinoviruses, wheezing, and asthma.

Journal of virology ·Vol. 84 ·No. 15 ·2010-08-00 ·Pages 7418-26

Gern JE

Abstract

Human rhinoviruses (HRVs) were discovered as common cold pathogens over 50 years ago. Recent advances in molecular viral diagnostics have led to an appreciation of their role in more-significant respiratory illnesses, including bronchiolitis in infancy, childhood pneumonia, and acute exacerbations of chronic respiratory diseases such as asthma, chronic obstructive lung disease, and cystic fibrosis. Until a few years ago, only two groups of HRVs (A and B) had been recognized. However, full and partial sequencing of HRVs led to the discovery of a third species of HRV (HRV-C) that has distinct structural and biologic features. Risk factors and pathogenic mechanisms for more-severe HRV infections are being defined, and yet fundamental questions persist about mechanisms relating this common pathogen to allergic diseases and asthma. The close relationship between HRV infections and asthma suggests that antiviral treatments could have a major impact on the morbidity associated with this chronic respiratory disease.

MeSH Terms
Asthma/etiology Humans Picornaviridae Infections/epidemiology,pathology,virology Respiratory Sounds/etiology Respiratory Tract Infections/epidemiology,pathology,virology Rhinovirus/classification,pathogenicity
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Gern James E
Department of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. gern@medicine.wisc.edu
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
1098-5514
DOI
10.1128/JVI.02290-09
Email
gern@medicine.wisc.edu
Published
2010-08-00
Epub
2010-00-07
Pages
7418-26
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC2897627
Subset
IM
Grants
NIAID NIH HHS · P01AI50500 · United States
NIAID NIH HHS · U19 AI070503 · United States
NIAID NIH HHS · P01 AI050500 · United States
NHLBI NIH HHS · P01HL070831 · United States
NHLBI NIH HHS · P01 HL070831 · United States
External Links
PubMed source DOI: 10.1128/JVI.02290-09 PMC Full Text View journal details
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