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PMID: 203651 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Human granulocyte generation of hydroxyl radical.

The Journal of experimental medicine ·Vol. 147 ·No. 2 ·1978-02-01 ·Pages 316-23

Weiss SJ, Rustagi PK, LoBuglio AF

Abstract

Human granulocytes were capable of oxidizing 2-keto-4 thiomethylbutyric acid to ethylene during phagocytosis or membrane perturbation. The reaction required hydrogen peroxide and superoxide and in addition was inhibited by various hydroxyl radical (OH) scavengers. These observations represent direct evidence for the generation of OH by human granulocytes. Further, inhibition of ethylene generation by azide and cyanide suggests that OH generation in granulocytes may be linked to myeloperoxidase.

MeSH Terms

Blood Bactericidal Activity Free Radicals Granulocytes/immunology,metabolism Humans Hydrogen Peroxide/blood Hydroxides/blood Leukocytes/metabolism Oxidation-Reduction Peroxidase/blood Phagocytosis Superoxides/blood

Chemicals

Free Radicals Hydroxides Superoxides Hydrogen Peroxide Peroxidase

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Weiss S J

Rustagi P K

LoBuglio A F

References (27)

27 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.147.2.316

Published

1978-02-01

Pages

316-23

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2184490

Subset

External Links

PubMed source DOI: 10.1084/jem.147.2.316 PMC Full Text View journal details

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