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PMID: 20363604 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Inflammatory cytokines as a third signal for T cell activation.

Current opinion in immunology ·Vol. 22 ·No. 3 ·2010-06-00 ·Pages 333-40

Curtsinger JM, Mescher MF

Abstract

CD8 T cells require a third signal, along with Ag and costimulation, to make a productive response and avoid death and/or tolerance induction. Recent studies indicate that IL-12 and Type I IFN (IFNalpha/beta) are the major sources of signal 3 in a variety of responses, and that the two cytokines stimulate a common regulatory program involving altered expression of about 350 genes. Signal 3-driven chromatin remodeling is likely to play a major role in this regulation. Although less well studied, there is emerging evidence that CD4 T cells may also require a 'third signal' for a productive response and that IL-1 can provide this signal. Signal 3 cytokines can replace adjuvants in supporting in vivo T cell responses to peptide and protein antigens, and a better understanding of their activities and mechanisms should contribute to more rational design of vaccines.

MeSH Terms
Animals CD8-Positive T-Lymphocytes/cytology,immunology Cytokines/biosynthesis,immunology Gene Expression Regulation/immunology Humans Inflammation/immunology,metabolism Lymphocyte Activation/immunology Mice Signal Transduction T-Lymphocytes/cytology,immunology
Chemicals
Cytokines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Curtsinger Julie M
Center for Immunology, Department of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Mescher Matthew F
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Article Info
Journal
Current opinion in immunology
Abbr.
Curr Opin Immunol
ISSN
1879-0372
DOI
10.1016/j.coi.2010.02.013
Published
2010-06-00
Epub
2010-00-02
Pages
333-40
Language
English
Region
England
NLM ID
8900118
PMCID
PMC2891062
Subset
IM
Grants
NIAID NIH HHS · R01 AI034824-16A1 · United States
NIAID NIH HHS · P01 AI035296-170004 · United States
NIAID NIH HHS · R01 AI34824 · United States
NIAID NIH HHS · R01 AI034824 · United States
NIAID NIH HHS · P01AI35296 · United States
NIAID NIH HHS · P01 AI035296 · United States
External Links
PubMed source DOI: 10.1016/j.coi.2010.02.013 PMC Full Text View journal details
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