Male development of chromosomally female mice transgenic for Sry.

Nature ·Vol. 351 ·No. 6322 ·1991-05-09 ·Pages 117-21

Koopman P, Gubbay J, Vivian N, Goodfellow P, Lovell-Badge R

Abstract

The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.

Related Genes

SRY sry

MeSH Terms

Animals DNA Female Humans Male Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Transgenic Morphogenesis/genetics Phenotype Regulatory Sequences, Nucleic Acid Restriction Mapping Sex Determination Analysis Species Specificity Testis/embryology X Chromosome Y Chromosome

Chemicals

DNA

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Koopman P

Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK.

Gubbay J

Vivian N

Goodfellow P

Lovell-Badge R

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/351117a0

Published

1991-05-09

Pages

117-21

Language

English

Region

England

NLM ID

0410462

Subset

Grants

Medical Research Council · MC_U117562207 · United Kingdom

Corrections

CommentIn

PMID: 2030741

External Links

PubMed source DOI: 10.1038/351117a0 View journal details

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Male development of chromosomally female mice transgenic for Sry.

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