Home LiteratureArticle Details
PMID: 2023912 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Human monoamine oxidase A and B genes exhibit identical exon-intron organization.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 9 ·1991-05-01 ·Pages 3637-41

Grimsby J, Chen K, Wang LJ, Lan NC, Shih JC

Abstract

Monoamine oxidases A and B [MAOA and MAOB; amine:oxygen oxidoreductase (deaminating) (flavin-containing), EC 1.4.3.4] play important roles in the metabolism of neuroactive, vasoactive amines and the Parkinsonism-producing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Human MAOA and MAOB genes isolated from X chromosome-specific libraries span at least 60 kilobases, consist of 15 exons, and exhibit identical exon-intron organization. Exon 12 codes for the covalent FAD-binding-site and is the most conserved exon; the MAOA and MAOB exon 12 products share 93.9% peptide identity. These results suggest that MAOA and MAOB are derived from duplication of a common ancestral gene and provide insight on the structural/functional relationship of the enzyme products.

Related Genes
MAOA MAOB
MeSH Terms
Base Sequence Exons Genes Humans Molecular Sequence Data Monoamine Oxidase/genetics Restriction Mapping
Chemicals
Monoamine Oxidase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Grimsby J
Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033.
Chen K
Wang L J
Lan N C
Shih J C
References (34)
34 references, click to expand
  1. Human liver MAO-A and MAO-B separated by immunoaffinity chromatography with MAO-B-specific monoclonal antibody.
    Science. 1982 Mar 12;215(4538):1400-3 PMID: 7063850
  2. Tissue distribution of human monoamine oxidase A and B mRNA.
    J Neurochem. 1990 Oct;55(4):1166-9 PMID: 2398352
  3. Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase.
    Biochem Biophys Res Commun. 1984 Apr 30;120(2):574-8 PMID: 6428396
  4. New contributions from basic science to understanding the effects of monoamine oxidase inhibiting antidepressants.
    J Clin Psychiatry. 1984 Jul;45(7 Pt 2):37-43 PMID: 6735994
  5. Expression of functional human monoamine oxidase A and B cDNAs in mammalian cells.
    J Neurochem. 1989 May;52(5):1652-4 PMID: 2496202
  6. Three alpha-amylase genes of Aspergillus oryzae exhibit identical intron-exon organization.
    Mol Microbiol. 1989 Jan;3(1):3-14 PMID: 2785629
  7. The primary structure of bovine monoamine oxidase type A. Comparison with peptide sequences of bovine monoamine oxidase type B and other flavoenzymes.
    Biochem J. 1989 Apr 15;259(2):407-13 PMID: 2719656
  8. Interaction of N-(2-nitro-4-azidophenyl)-serotonin with two types of monoamine oxidase in rat brain.
    J Neurochem. 1984 Dec;43(6):1680-7 PMID: 6491673
  9. A 70-kd protein of the yeast mitochondrial outer membrane is targeted and anchored via its extreme amino terminus.
    EMBO J. 1984 Dec 20;3(13):3157-64 PMID: 6396085
  10. 4-Fluoro-3-nitrophenyl azide, a selective photoaffinity label for type B monoamine oxidase.
    Biochem Pharmacol. 1985 Mar 15;34(6):781-8 PMID: 3977955
  11. Distinct monoamine oxidase A and B populations in primate brain.
    Science. 1985 Oct 11;230(4722):181-3 PMID: 3875898
  12. The complete amino acid sequence of the human aldolase C isozyme derived from genomic clones.
    Biochimie. 1987 Feb;69(2):137-45 PMID: 3105602
  13. Intron/exon structure of the human gene for the muscle isozyme of glycogen phosphorylase.
    Proteins. 1987;2(3):177-87 PMID: 3447177
  14. cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties.
    Proc Natl Acad Sci U S A. 1988 Jul;85(13):4934-8 PMID: 3387449
  15. Structural features of human monoamine oxidase A elucidated from cDNA and peptide sequences.
    J Neurochem. 1988 Oct;51(4):1321-4 PMID: 3418353
  16. Molecular cloning of a cDNA for rat liver monoamine oxidase B.
    Biochem Biophys Res Commun. 1988 Dec 30;157(3):970-6 PMID: 2974701
  17. Steroid regulation of monoamine oxidase activity in the adrenal medulla.
    FASEB J. 1989 Apr;3(6):1753-9 PMID: 2495232
  18. An appraisal of the use of monoamine oxidase as an enzyme marker for the outer membrane of rat liver mitochondria.
    J Cell Biol. 1970 Jul;46(1):173-9 PMID: 5460462
  19. Some observations upon a new inhibitor of monoamine oxidase in brain tissue.
    Biochem Pharmacol. 1968 Jul;17(7):1285-97 PMID: 5659776
  20. The covalently-bound flavin of hepatic monoamine oxidase. 1. Isolation and sequence of a flavin peptide and evidence for binding at the 8alpha position.
    Eur J Biochem. 1971 Dec;24(2):321-7 PMID: 4333601
  21. Some puzzling pharmacological effects of monoamine oxidase inhibitors.
    Adv Biochem Psychopharmacol. 1972;5:393-408 PMID: 5066229
  22. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
  23. Low platelet monoamine oxidase activity and schizophrenia.
    Schizophr Bull. 1976;2(1):77-89 PMID: 779021
  24. Studies on monoamine oxidase. XVIII. Enzymic properties of placental monoamine oxidase.
    Jpn J Pharmacol. 1976 Aug;26(4):493-500 PMID: 12389
  25. Monoamine oxidase A and B: a useful concept?
    Biochem Pharmacol. 1978 Jan 1;27(1):97-101 PMID: 619909
  26. DNA sequencing with chain-terminating inhibitors.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
  27. Familial biochemical and clinical correlates of alcoholics with low platelet monoamine oxidase activity.
    Biol Psychiatry. 1979 Apr;14(2):385-94 PMID: 476226
  28. Development of benzylamine oxidase and monoamine oxidase A and B in man.
    Biochem Pharmacol. 1980 May 1;29(9):1221-30 PMID: 7397007
  29. Elevated platelet monoamine oxidase activity in patients wth nonendogenous depression.
    Am J Psychiatry. 1980 Oct;137(10):1258-9 PMID: 7416279
  30. Studies on the pargyline-binding site of different types of monoamine oxidase.
    Can J Biochem. 1981 Jan;59(1):30-7 PMID: 6784898
  31. Organization and expression of eucaryotic split genes coding for proteins.
    Annu Rev Biochem. 1981;50:349-83 PMID: 6791577
  32. Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease.
    Genomics. 1989 May;4(4):552-9 PMID: 2744764
  33. Primary structure of rat monoamine oxidase A deduced from cDNA and its expression in rat tissues.
    Agric Biol Chem. 1990 Jan;54(1):253-7 PMID: 1368522
  34. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
    Anal Biochem. 1983 Jul 1;132(1):6-13 PMID: 6312838
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.88.9.3637
Published
1991-05-01
Pages
3637-41
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC51507
Subset
IM
Grants
NIMH NIH HHS · KO5 MH00796 · United States
NIMH NIH HHS · R01 MH 37020 · United States
NIMH NIH HHS · R37MH39085 · United States
Databases
GENBANK
M68843, M68844, M68845, M68846, M68847, M68848, M68849, M68850, M68851, M68852
External Links
PubMed source DOI: 10.1073/pnas.88.9.3637 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2