MicroRNAs--targeting and target prediction.

New biotechnology ·Vol. 27 ·No. 3 ·2010-07-31 ·Pages 243-9

Saito T, Saetrom P

Abstract

MicroRNAs (miRNAs) are a class of small noncoding RNAs that can regulate many genes by base pairing to sites in mRNAs. The functionality of miRNAs overlaps that of short interfering RNAs (siRNAs), and many features of miRNA targeting have been revealed experimentally by studying miRNA-mimicking siRNAs. This review outlines the features associated with animal miRNA targeting and describes currently available prediction tools.

MeSH Terms

3' Untranslated Regions Animals Base Sequence Gene Targeting Humans MicroRNAs/genetics,metabolism RNA, Small Interfering/genetics,metabolism

Chemicals

3' Untranslated Regions MicroRNAs RNA, Small Interfering

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Saito Takaya

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO-7489 Trondheim, Norway.

Saetrom Pal

Article Info

Journal

New biotechnology

Abbr.

N Biotechnol

ISSN

1876-4347

DOI

10.1016/j.nbt.2010.02.016

Published

2010-07-31

Epub

2010-00-26

Pages

243-9

Language

English

Region

Netherlands

NLM ID

101465345

Subset

External Links

PubMed source DOI: 10.1016/j.nbt.2010.02.016 View journal details

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