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PMID: 20202892 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective.

Current opinion in chemical biology ·Vol. 14 ·No. 3 ·2010-06-00 ·Pages 308-14

Bauer RA, Wurst JM, Tan DS

Abstract

Existing drugs address a relatively narrow range of biological targets. As a result, libraries of drug-like molecules have proven ineffective against a variety of challenging targets, such as protein-protein interactions, nucleic acid complexes, and antibacterial modalities. In contrast, natural products are known to be effective at modulating such targets, and new libraries are being developed based on underrepresented scaffolds and regions of chemical space associated with natural products. This has led to several recent successes in identifying new chemical probes that address these challenging targets.

MeSH Terms
Animals DNA-Binding Proteins Drug Delivery Systems/methods Drug Discovery/methods High-Throughput Screening Assays Humans Protein Interaction Mapping Small Molecule Libraries
Chemicals
DNA-Binding Proteins Small Molecule Libraries
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bauer Renato A
Tri-Institutional Training Program in Chemical Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 422, New York, NY 10065, USA.
Wurst Jacqueline M
Tan Derek S
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Article Info
Journal
Current opinion in chemical biology
Abbr.
Curr Opin Chem Biol
ISSN
1879-0402
DOI
10.1016/j.cbpa.2010.02.001
Published
2010-06-00
Epub
2010-00-02
Pages
308-14
Language
English
Region
England
NLM ID
9811312
PMCID
PMC2878877
Subset
IM
Grants
NCI NIH HHS · T32 CA062948 · United States
NIGMS NIH HHS · P41 GM076267-02 · United States
NIGMS NIH HHS · P41 GM076267-01 · United States
NIGMS NIH HHS · P41 GM076267 · United States
NIGMS NIH HHS · P41 GM076267-03S1 · United States
NIGMS NIH HHS · P41 GM076267-03 · United States
External Links
PubMed source DOI: 10.1016/j.cbpa.2010.02.001 PMC Full Text View journal details
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