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PMID: 20179347 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Comment

Resisting arrest: a switch from angiogenesis to vasculogenesis in recurrent malignant gliomas.

The Journal of clinical investigation ·Vol. 120 ·No. 3 ·2010-03-00 ·Pages 663-7

Greenfield JP, Cobb WS, Lyden D

Abstract

The cellular and molecular events that initiate and promote malignant glioma development are not completely understood. The treatment modalities designed to promote its demise are all ultimately ineffective, leading to disease progression. In this issue of the JCI, Kioi et al. demonstrate that vasculogenesis and angiogenesis potentially play distinct roles in the etiology of primary and recurrent malignant gliomas, suggesting that patient therapy should perhaps be tailored specifically against the predominant vasculature pathway at a given specific stage of gliomagenesis.

MeSH Terms
Animals Anti-HIV Agents Antibodies, Neutralizing Antineoplastic Agents/pharmacology,therapeutic use Benzylamines Bone Marrow Cells/metabolism,pathology Brain Neoplasms/metabolism,pathology,therapy CD11b Antigen/metabolism Cell Line, Tumor Cell Movement/drug effects,radiation effects Chemokine CXCL12/antagonists & inhibitors,metabolism Cyclams Glioblastoma/metabolism,pathology,therapy Heterocyclic Compounds/pharmacology,therapeutic use Humans Hypoxia-Inducible Factor 1/metabolism Mice Mice, Nude Monocytes/metabolism,pathology Neoplasm Recurrence, Local/metabolism,pathology,therapy Neoplasm Transplantation Neovascularization, Pathologic/metabolism,pathology,therapy Receptors, CXCR4/antagonists & inhibitors,metabolism Transplantation, Heterologous Whole-Body Irradiation
Chemicals
Anti-HIV Agents Antibodies, Neutralizing Antineoplastic Agents Benzylamines CD11b Antigen CXCR4 protein, human CXCR4 protein, mouse Chemokine CXCL12 Cxcl12 protein, mouse Cyclams Heterocyclic Compounds Hypoxia-Inducible Factor 1 ITGAM protein, human Receptors, CXCR4 plerixafor
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Greenfield Jeffrey P
Pediatric Brain Tumor Research and Children's Cancer and Blood Foundation Laboratories, Champalimaud Metastasis Programme, New York, New York, USA. jpgreenf@med.cornell.edu
Cobb William S
Lyden David
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
1558-8238
DOI
10.1172/JCI42345
Email
jpgreenf@med.cornell.edu
Published
2010-03-00
Epub
2010-00-22
Pages
663-7
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC2827970
Subset
IM
Corrections
CommentOn
PMID: 20179352
External Links
PubMed source DOI: 10.1172/JCI42345 PMC Full Text View journal details
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