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PMID: 201667 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Mechanisms contributing to malignant dysrhythmias induced by ischemia in the cat.

The Journal of clinical investigation ·Vol. 61 ·No. 1 ·1978-01-00 ·Pages 109-19

Corr PB, Witkowski FX, Sobel BE

Abstract

Continuously recorded bipolar electrograms were obtained simultaneously from epi-, endo-, and mid-myocardial regions of the ischemic and normal zones of cat left ventricle in vivo after coronary occlusion, analyzed by computer, and compared to regional cyclic AMP levels. Regional cyclic AMP content was used as an index of the combined local effects of: (a) efferent sympathetic nerve discharge; (b) release of myocardial catecholamines due to ischemia; and (c) circulating catecholamines. Ischemia resulted in a progressive increase in pulse width and rise time and a decrease in rate of rise of voltage (dV/dt) of the local electrograms from ischemic zones reaching a maximum within 2.4+/-0.3 min (mean+/-SE) at the time of onset of severe ventricular dysrhythmias, all of which returned toward control before the cessation of the dysrhythmia (33.5+/-1.5 min after coronary occlusion). Increases in cyclic AMP in ischemic zones preceded corresponding increases in the frequency of premature ventricular complexes (PVCs). Propranolol inhibited the increases in cyclic AMP and reduced the frequency of PVCs in animals without ventricular fibrillation. In animals with ventricular fibrillation, cyclic AMP was significantly elevated in normal and ischemic zones compared to animals with PVCs only. Electrical induction of PVCs or ventricular fibrillation in ischemic and nonischemic hearts failed to increase cyclic AMP. The results suggest that the changes in regional adrenergic stimulation of the heart may contribute to perpetuation of ventricular dysrhythmia and the genesis of ventricular fibrillation early after the onset of myocardial ischemia.

MeSH Terms
Animals Arrhythmias, Cardiac/physiopathology Cats Coronary Disease/metabolism,physiopathology Cyclic AMP/analysis Electrocardiography Female Heart/physiopathology Male Myocardium/analysis,metabolism Propranolol/pharmacology Ventricular Fibrillation/metabolism
Chemicals
Propranolol Cyclic AMP
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Corr P B
Witkowski F X
Sobel B E
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41 references, click to expand
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI108908
Published
1978-01-00
Pages
109-19
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC372519
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI108908 PMC Full Text View journal details
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