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题目:: Triple-negative breast cancer: role of the androgen receptor.
作者:: Gucalp(Ayca),Traina(Tiffany A)
状态:: 发布时间2010-02-18 , 更新时间 2014-11-20
期刊:: Cancer J
摘要:: The androgen receptor (AR), a member of the steroid hormone receptor family, is expressed in more than 70% of breast cancers and has been implicated in breast cancer pathogenesis. The role of the AR is of particular interest in patients with estrogen- and progesterone receptor negative and HER2-negative cancers, which represent approximately 25% of all breast cancers. The "triple-negative" subset of tumors generally has a more aggressive clinical course and does not benefit from conventional endocrine targeted therapies. However, emerging evidence suggests that the AR may serve as a therapeutic target for a subset of triple-negative breast cancers. Herein, we review the role of the AR in breast cancer tumorigenesis and current progress and future directions in the development of AR-targeted therapies.
语言:: eng
DOI:: 10.1097/PPO.0b013e3181ce4ae1

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