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PMID: 2013406 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Nucleotide sequence of the LYS2 gene of Saccharomyces cerevisiae: homology to Bacillus brevis tyrocidine synthetase 1.

Gene ·Vol. 98 ·No. 1 ·1991-02-01 ·Pages 141-5

Morris ME, Jinks-Robertson S

Abstract

The Saccharomyces cerevisiae LYS2 gene, which encodes alpha-aminoadipate reductase, an essential enzyme in the yeast lysine biosynthetic pathway, has been sequenced. A large open reading frame (ORF) has been identified which can specify a 1392-amino acid protein with a deduced Mr of 155,344. A DNA database search using the translated LYS2 ORF as a probe has revealed significant aa sequence homology to the Bacillus brevis enzyme tyrocidine synthetase 1.

Related Genes
LYS2 tycA
MeSH Terms
Aldehyde Oxidoreductases/genetics Amino Acid Sequence Bacillus/enzymology,genetics Base Sequence DNA, Bacterial DNA, Fungal Genes, Bacterial Genes, Fungal L-Aminoadipate-Semialdehyde Dehydrogenase Molecular Sequence Data Open Reading Frames Peptide Synthases/genetics,metabolism Restriction Mapping Saccharomyces cerevisiae/enzymology,genetics Sequence Homology, Nucleic Acid
Chemicals
DNA, Bacterial DNA, Fungal Aldehyde Oxidoreductases L-Aminoadipate-Semialdehyde Dehydrogenase Peptide Synthases tyrocidine synthetase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Morris M E
Department of Biology, Emory University, Atlanta, GA 30322.
Jinks-Robertson S
Article Info
Journal
Gene
Abbr.
Gene
ISSN
0378-1119
DOI
10.1016/0378-1119(91)90117-t
Published
1991-02-01
Pages
141-5
Language
English
Region
Netherlands
NLM ID
7706761
Subset
IM
Grants
NIGMS NIH HHS · GM38464 · United States
Databases
GENBANK
M36287, M37851, M37852, M63445, M74185, S75878, X52535, X52536, X52537, X52538
External Links
PubMed source DOI: 10.1016/0378-1119(91)90117-t View journal details
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