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PMID: 20133134 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

ADF/cofilin: a functional node in cell biology.

Trends in cell biology ·Vol. 20 ·No. 4 ·2010-04-00 ·Pages 187-95

Bernstein BW, Bamburg JR

Abstract

Recent findings have significantly expanded our understanding of the regulation of actin-depolymerizing factor (ADF)/cofilin proteins and the profound multifaceted impact that these well-established regulators of actin dynamics have on cell biology. In this review we discuss new aspects of previously documented regulation, such as phosphorylation, but also cover novel recently established modes of regulation and functions of ADF (also known as destrin)/cofilin. We now understand that their activity responds to a vast array of inputs far greater than previously appreciated and that these proteins not only feed back to the crucially important dynamics of actin, but also to apoptosis cascades, phospholipid metabolism, and gene expression. We argue that this ability to respond to physiological changes by modulating those same changes makes the ADF/cofilin protein family a homeostatic regulator or 'functional node' in cell biology.

MeSH Terms
Actin Depolymerizing Factors/chemistry,genetics,metabolism Actins/metabolism Animals Destrin/chemistry,genetics,metabolism Fibroblasts/cytology,metabolism Gene Expression Regulation HeLa Cells/cytology,metabolism Humans Mice Models, Molecular Neurons/cytology,metabolism
Chemicals
Actin Depolymerizing Factors Actins Destrin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bernstein Barbara W
Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870, USA. Barbara.Bernstein@ColoState.edu
Bamburg James R
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Article Info
Journal
Trends in cell biology
Abbr.
Trends Cell Biol
ISSN
1879-3088
DOI
10.1016/j.tcb.2010.01.001
Email
barbara.bernstein@colostate.edu
Published
2010-04-00
Epub
2010-00-03
Pages
187-95
Language
English
Region
England
NLM ID
9200566
PMCID
PMC2849908
Subset
IM
Grants
NINDS NIH HHS · R01 NS040371 · United States
NINDS NIH HHS · R01 NS040371-08 · United States
NINDS NIH HHS · NS40371 · United States
External Links
PubMed source DOI: 10.1016/j.tcb.2010.01.001 PMC Full Text View journal details
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