Polymyxin B and rifampin: new regimen for multiresistant Serratia marcescens infections.

Antimicrobial agents and chemotherapy ·Vol. 12 ·No. 6 ·1977-12-00 ·Pages 655-9

Ostenson RC, Fields BT, Nolan CM

Abstract

Polymyxin B and rifampin were given to 12 patients with multi-drug-resistant nosocomial Serratia marcescens infections. Eight cures were achieved; drug hepatotoxicity occurred once; one fatal suprainfection was encountered; and two patients died during therapy of causes related to severe underlying illnesses. Polymyxin B and rifampin were uniformly synergistic in vitro against the infecting strains and against 40 additional clinical isolates of S. marcescens.

MeSH Terms

Adult Aged Drug Resistance, Microbial Enterobacteriaceae Infections/drug therapy Female Humans Male Middle Aged Polymyxin B/administration & dosage,pharmacology Polymyxins/administration & dosage Rifampin/administration & dosage,pharmacology Serratia marcescens/drug effects

Chemicals

Polymyxins Polymyxin B Rifampin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Ostenson R C

Fields B T

Nolan C M

References (12)

12 references, click to expand

Detection of Serratia outbreaks in hospital.
Lancet. 1976 Aug 28;2(7983):455-9 PMID: 73753
Amikacin resistance developing in patients with Pseudomonas aeruginosa bronchopneumonia.
Lancet. 1977 Mar 5;1(8010):537-8 PMID: 65626
Amikacin therapy of patients with multiply antibiotic-resistant Serratia marcescens infections: development of increasing resistance during therapy.
Am J Med. 1977 Jun;62(6):902-10 PMID: 326046
The polymyxins.
Med Clin North Am. 1970 Sep;54(5):1257-65 PMID: 4319624
Gentamicin-resistant Pseudomonas aeruginosa and Serratia marcescens in a general hospital.
Lancet. 1976 Mar 13;1(7959):580-3 PMID: 55850
Sulfamethoxazole-trimethoprim-polymyxin therapy of serious multiply drug-resistant Serratia infections.
Antimicrob Agents Chemother. 1976 Feb;9(2):201-7 PMID: 178273
In vitro additive effect of polymxin B and rifampin against Serratia marcesen.
Antimicrob Agents Chemother. 1975 Jun;7(6):874-6 PMID: 168807
Bacterial colonization and clinical superinfection of the respiratory tract complicating antibiotic treatment of pneumonia.
J Infect Dis. 1969 Jun;119(6):597-624 PMID: 4893892
Comparison of methods for assessing in vitro antibiotic synergism against Pseudomonas and Serratia.
J Lab Clin Med. 1975 Nov;86(5):853-62 PMID: 810533
Amikacin therapy for severe gram-negative sepsis. Emphasis on infections with gentamicin-resistant organisms.
Ann Intern Med. 1975 Oct;83(4):484-8 PMID: 1101761
Emergence of resistance to amikacin during treatment of burn wounds: the role of antimicrobial susceptibility testing.
Surgery. 1976 Feb;79(02):224-8 PMID: 1246678
Amikacin therapy for serious gram-negative bacillary infections.
Ann Intern Med. 1975 Dec;83(6):790-800 PMID: 1200524

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.12.6.655

Published

1977-12-00

Pages

655-9

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC429999

Subset

External Links

PubMed source DOI: 10.1128/AAC.12.6.655 PMC Full Text View journal details

Analysis Services

Polymyxin B and rifampin: new regimen for multiresistant Serratia marcescens infections.

Contact

WeChat Official Account