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PMID: 2010436 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Cell regulation by sphingosine and more complex sphingolipids.

Journal of bioenergetics and biomembranes ·Vol. 23 ·No. 1 ·1991-02-00 ·Pages 83-104

Merrill AH

Abstract

Sphingolipids have the potential to regulate cell behavior at essentially all levels of signal transduction. They serve as cell surface receptors for cytoskeletal proteins, immunoglobulins, and some bacteria; as modifiers of the properties of cell receptors for growth factors (and perhaps other agents); and as activators and inhibitors of protein kinases, ion transporters, and other proteins. Furthermore, the biological activity of these compounds resides not only in the more complex species (e.g., sphingomyelin, cerebrosides, gangliosides, and sulfatides), but also in their turnover products, such as the sphingosine backbone which inhibits protein kinase C and activates the EGF-receptor kinase, inter alia. Since sphingolipids change with cell growth, differentiation, and neoplastic transformation, they could be vital participants in the regulation of these processes.

MeSH Terms
Animals Humans Models, Biological Molecular Structure Signal Transduction Sphingolipids/metabolism Sphingosine/metabolism
Chemicals
Sphingolipids Sphingosine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Merrill A H
Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322.
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Article Info
Journal
Journal of bioenergetics and biomembranes
Abbr.
J Bioenerg Biomembr
ISSN
0145-479X
DOI
10.1007/BF00768840
Published
1991-02-00
Pages
83-104
Language
English
Region
United States
NLM ID
7701859
Subset
IM
Grants
NIGMS NIH HHS · GM33369 · United States
External Links
PubMed source DOI: 10.1007/BF00768840 View journal details
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