Ductal origin hypothesis of pancreatic regeneration under attack.

Cell metabolism ·Vol. 11 ·No. 1 ·2010-01-00 ·Pages 2-3

Kushner JA, Weir GC, Bonner-Weir S

Abstract

暂无摘要

MeSH Terms

Animals Cell Lineage Insulin-Secreting Cells/physiology Mice Pancreatic Ducts/physiology Regeneration Stem Cells/physiology

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Kushner Jake A

Weir Gordon C

Bonner-Weir Susan

References (10)

10 references, click to expand

All beta cells contribute equally to islet growth and maintenance.
PLoS Biol. 2007 Jul;5(7):e163 PMID: 17535113
A role for islet neogenesis in curing diabetes.
Diabetologia. 2009 May;52(5):735-8 PMID: 19271208
Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas.
Cell. 2008 Jan 25;132(2):197-207 PMID: 18243096
Recovery from diabetes in mice by beta cell regeneration.
J Clin Invest. 2007 Sep;117(9):2553-61 PMID: 17786244
Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan.
Diabetologia. 2004 Feb;47(2):259-65 PMID: 14666367
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation.
Nature. 2004 May 6;429(6987):41-6 PMID: 15129273
Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth.
Dev Cell. 2009 Dec;17(6):849-60 PMID: 20059954
Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth.
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19915-9 PMID: 19052237
Growth and regeneration of adult beta cells does not involve specialized progenitors.
Dev Cell. 2007 May;12(5):817-26 PMID: 17488631
Cellular origins of beta-cell regeneration: a legacy view of historical controversies.
J Intern Med. 2009 Oct;266(4):325-38 PMID: 19765178

Article Info

Journal

Cell metabolism

Abbr.

Cell Metab

ISSN

1932-7420

DOI

10.1016/j.cmet.2009.12.005

Published

2010-01-00

Pages

2-3

Language

English

Region

United States

NLM ID

101233170

PMCID

PMC3762572

Subset

Grants

NIDDK NIH HHS · P30 DK036836 · United States

NIDDK NIH HHS · R01 DK044523 · United States

NIDDK NIH HHS · R01 DK066056 · United States

NIDDK NIH HHS · R01 DK081469 · United States

Corrections

ErratumIn

External Links

PubMed source DOI: 10.1016/j.cmet.2009.12.005 PMC Full Text View journal details

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Ductal origin hypothesis of pancreatic regeneration under attack.

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