EML4-ALK fusion in lung.

The American journal of pathology ·Vol. 176 ·No. 3 ·2010-03-00 ·Pages 1552-3; author reply 1553-4

Mano H, Takeuchi K

Abstract

暂无摘要

MeSH Terms

Carcinoma, Non-Small-Cell Lung/metabolism Clinical Trials as Topic DNA, Complementary/genetics Enzyme Inhibitors/pharmacology Exons/genetics Humans Immunohistochemistry Lung/metabolism,pathology Lung Neoplasms/metabolism Oncogene Proteins, Fusion/antagonists & inhibitors,genetics,metabolism Polymerase Chain Reaction

Chemicals

DNA, Complementary EML4-ALK fusion protein, human Enzyme Inhibitors Oncogene Proteins, Fusion

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Mano Hiroyuki

Takeuchi Kengo

References (12)

12 references, click to expand

EML4-ALK fusion lung cancer: a rare acquired event.
Neoplasia. 2008 Mar;10(3):298-302 PMID: 18320074
Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers.
Mol Cancer Res. 2009 Sep;7(9):1466-76 PMID: 19737969
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Cell. 2007 Dec 14;131(6):1190-203 PMID: 18083107
MET gene copy number in non-small cell lung cancer: molecular analysis in a targeted tyrosine kinase inhibitor naïve cohort.
J Thorac Oncol. 2008 Apr;3(4):331-9 PMID: 18379349
EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues.
Am J Pathol. 2009 Feb;174(2):661-70 PMID: 19147828
The NPM-ALK and the ATIC-ALK fusion genes can be detected in non-neoplastic cells.
Am J Pathol. 2001 Jun;158(6):2185-93 PMID: 11395396
The EML4-ALK transcript but not the fusion protein can be expressed in reactive and neoplastic lymphoid tissues.
Haematologica. 2009 Sep;94(9):1307-11 PMID: 19734424
KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer.
Clin Cancer Res. 2009 May 1;15(9):3143-9 PMID: 19383809
Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts.
Clin Cancer Res. 2008 Oct 15;14(20):6618-24 PMID: 18927303
Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer.
Cancer Res. 2008 Jul 1;68(13):4971-6 PMID: 18593892
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer.
Nature. 2007 Aug 2;448(7153):561-6 PMID: 17625570
Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population.
Clin Cancer Res. 2009 Aug 15;15(16):5216-23 PMID: 19671850

Article Info

Journal

The American journal of pathology

Abbr.

Am J Pathol

ISSN

1525-2191

DOI

10.2353/ajpath.2010.091057

Published

2010-03-00

Epub

2010-00-14

Pages

1552-3; author reply 1553-4

Language

English

Region

United States

NLM ID

0370502

PMCID

PMC2832173

Subset

Corrections

CommentOn

PMID: 19147828

External Links

PubMed source DOI: 10.2353/ajpath.2010.091057 PMC Full Text View journal details

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