Circulating tumor cells: a window into cancer biology and metastasis.
The presence of circulating tumor cells (CTCs) accompanies tumor invasion into the bloodstream. Detection, monitoring, and molecular analysis of these rare cancer cells shed into blood will provide a powerful and noninvasive approach for the detection of early disease, assessing prognosis and therapeutic response in established cancers, and targeting metastatic precursor cells. We review current and emerging technologies for CTC isolation, with a focus on capture efficiency, purity, and viability of CTCs, and their potential clinical applications.
17 references, click to expand
-
Circulating tumor cells, disease progression, and survival in metastatic breast cancer.N Engl J Med. 2004 Aug 19;351(8):781-91 PMID: 15317891
-
Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells.J Chromatogr A. 2007 Aug 31;1162(2):154-61 PMID: 17561026
-
Isolation of rare circulating tumour cells in cancer patients by microchip technology.Nature. 2007 Dec 20;450(7173):1235-9 PMID: 18097410
-
High speed detection of circulating tumor cells.Biosens Bioelectron. 2006 Apr 15;21(10):1893-9 PMID: 16464570
-
Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer.J Clin Oncol. 2005 Mar 1;23(7):1420-30 PMID: 15735118
-
Circulating tumor cell number and prognosis in progressive castration-resistant prostate cancer.Clin Cancer Res. 2007 Dec 1;13(23):7053-8 PMID: 18056182
-
Stem cells, cancer, and cancer stem cells.Nature. 2001 Nov 1;414(6859):105-11 PMID: 11689955
-
Detection of mutations in EGFR in circulating lung-cancer cells.N Engl J Med. 2008 Jul 24;359(4):366-77 PMID: 18596266
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.N Engl J Med. 2004 May 20;350(21):2129-39 PMID: 15118073
-
[Detection and quantification of circulating tumor cells in peripheral blood in patients with colon cancer].Med Clin (Barc). 2007 Sep 15;129(9):333-4 PMID: 17910847
-
Circulating tumor cell analysis in patients with progressive castration-resistant prostate cancer.Clin Cancer Res. 2007 Apr 1;13(7):2023-9 PMID: 17404082
-
The basics of epithelial-mesenchymal transition.J Clin Invest. 2009 Jun;119(6):1420-8 PMID: 19487818
-
Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases.Clin Cancer Res. 2004 Oct 15;10(20):6897-904 PMID: 15501967
-
Optimization of an enrichment process for circulating tumor cells from the blood of head and neck cancer patients through depletion of normal cells.Biotechnol Bioeng. 2009 Feb 1;102(2):521-34 PMID: 18726961
-
Circulating tumour cells as prognostic markers in progressive, castration-resistant prostate cancer: a reanalysis of IMMC38 trial data.Lancet Oncol. 2009 Mar;10(3):233-9 PMID: 19213602
-
In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry.Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11760-5 PMID: 17601776
-
A rare-cell detector for cancer.Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10501-4 PMID: 15249663
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